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Nek6 nın K562 Hücre Hatlarında Çoklu İlaç Dirençliliği ve Apoptoz Üzerindeki Etkileri
Date
2016-02-24
Author
Nabioğlu, Ayça
Mutlu, Pelin
Yalçın Azarkan, Serap
Gündüz, Ufuk
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https://hdl.handle.net/11511/83737
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The Role of NEK6 gene expression in multidrug resistance and apoptosis in MCF-7 and K-562 cell lines
Nabioğlu, Ayça; Gündüz, Ufuk; Mutlu, Pelin; Department of Biology (2015)
Grey mold disease is one of these postharvest decays. Especially grapes are infected by Botrytis cinerea known as a causal agent of the grey mold disease. Some fungicides are used to control this disease. However, they cause funcide- resistant strains of the pathogens and make hazardous for human health and environmental safety. Therefore, The killer yeasts are considered as promising alternative antifungal agents among other biocontrol agents. Pichia anomala which is a killer yeast secretes the K5 type yea...
NEK6’nın Apoptoz, Hücre Döngüsü ve İnvasyon Üzerindeki Etkisinin Prednizon Dirençli Multipl Miyelom Hücre Hattında İncelenmesi
Gündüz, Ufuk; Mutlu, Pelin; Keskin, Dilek(2015-12-31)
Mitotik hücre döngüsünün hatasız bir şekilde başlaması ve devam etmesinde önemli role sahip olan NEK6, NIMA-ilişkili (Nek) serin-treonin kinazlardan birisidir. Son zamandaki çalışmalar, NEK6 gen mutasyonlarının; iğ ipliklerinde bozukluklara, anormal kromozom ayrılmasına, mitozun durdurulmasında ve apoptozda sorunlara neden olduğu göstermektedir.Bu çalışmada ilaç dirençli RPMI-8226 miyelom hücre hattında NEK6 gen ifadesi, siRNA ile susturularak, hücre döngüsü, DNA hasar yanıtı ve apoptozda rol aldığı bilinen...
Effects of dynamic loading on neocartilage formation
Çiçek Rezaeitabar, Gülçin; Tezcaner, Ayşen; Altunbaş, Korhan; Department of Biomedical Engineering (2022-8-09)
Cartilage tissue engineering has gained attention to meet the increasing demand for articular cartilage treatment in ageing populations. In this study, a visible light crosslinkable Methacrylated Glycol Chitosan (MeGC)-Fibrinogen (Fib) hydrogel system which can potentially be used in cartilage tissue engineering applications was developed. Incorporation of Fib into MeGC hydrogel structure decreased the swelling, led to increase in stability and improved the mechanical properties of hydrogels. Besides Fib ad...
Behavior of neuro-2A cells on femtosecond laser structured silicon substrates
Mingu, Sara; Bek, Alpan; Department of Micro and Nanotechnology (2020)
Cells are known to interact with their physical environment and respond to cues such as substrate topography. Knowledge of the cell responses to topography may give information about cell behavior in health and disease, as well as be exploited in order to exert control on cells for various purposes. Cell responses to topography are dependent on cell type, substrate material and topographical features. In the present study, Neuro-2a cell line was used as a versatile and widely available neuronal cell model. ...
Neotetis Okyanusal Litosferinin Petrolojisine Mineral Kimyası Yaklaşımı: Aylı Dağ Ofiyolitik Diziliminden Bir Örnek Çalışma
Toksoy Köksal, Fatma; Küçük, Aynur(2017-12-31)
Önerilen bu çalışma kapsamında Aylı Dağ Ofiyolitlerinde detay petrografiye dayalı mineral kristolokimyası ağırlıklı bir çalışma yapılacak olup tüm-kayaç element ile izotop jeokimyası bulgularıyla desteklenecektir. Bu doğrultuda litosferik mantodan volkaniklere tüm birimlerin (manto peridotiti, kümülatlar, dayklar ve bazaltlar) jenetik ilişkileri irdelenerek petrolojik özellikleri ve tektonomagmatik karakterlerinin belirlenmesi amaçlanmaktadır. Çalışmanın mineral kimyası esasına dayandırılmış olması; tüm-kay...
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A. Nabioğlu, P. Mutlu, S. Yalçın Azarkan, and U. Gündüz, “Nek6 nın K562 Hücre Hatlarında Çoklu İlaç Dirençliliği ve Apoptoz Üzerindeki Etkileri,” 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/83737.