Multiomics-Engaging colors

Date

2019-03-28

Author

Özcan Kabasakal, Süreyya

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High-throughput omics technologies have revolutionised biological researchby enhancing our understanding of fundamental molecular processes. Despitethe recent advances in evolutionary genomics, human brain development isstill poorly understood. We have combined transcriptomics with four massspectrometry (MS)-based omics technologies: proteomics, metallomics,glycomics and lipidomics, to gain new insights into human braindevelopment. The integrated multiomics approach was employed toinvestigate the human dorsolateral prefrontal cortex (DLPFC) throughoutpost-natal development from 69 individuals aged six weeks to 49 years. TheDLPFC is implicated in a variety of complex behaviors and strongly linked topersonality development. High-dimensional data was analyzed using rigorousstatistical methods at different post-natal developmental stages acrossmultiple omics layers. This integrative multiomics approach reveals novelinsights into the critical stages of cognitive development.

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http://2019.khupo.org/index.php?g_page=pro&m_page=pro04&cate=21
https://hdl.handle.net/11511/83783

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Citation Formats

S. Özcan Kabasakal, “Multiomics-Engaging colors,” 2019, Accessed: 00, 2021. [Online]. Available: http://2019.khupo.org/index.php?g_page=pro&m_page=pro04&cate=21.