Apobec3B expression in drug resistant MCF 7 breast cancer cell lines

Date

2016-09-09

Author

Öngürü, Önder
Yalçın Azarkan, Serap
Rosembilt, C
Zhang, P
Kiliç, Selim
Gündüz, Ufuk

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URI

https://hdl.handle.net/11511/85240

Conference Name

EACR 24, (9 - 12 Temmuz 2016)

Collections

Graduate School of Natural and Applied Sciences, Conference / Seminar

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APOBEC3B expression in drug resistant MCF-7 breast cancer cell lines Onguru, Onder; Yalcin, Serap; Rosemblit, Cinthia; Zhang, Paul J.; Kilic, Selim; Gündüz, Ufuk (2016-04-01) APOBEC3B belongs to a protein family of cytidine deaminases that can insert mutations in DNA and RNA as a result of their ability to deaminate cytidine to uridine. It has been shown that APOBEC3B-catalysed deamination provides a chronic source of DNA damage in breast cancers. We investigated APOBEC3B expression in four drug resistant breast cancer cell lines (Doxorubicin, Etoposide, Paclitaxel and Docetaxel resistant MCF-7 cell lines) using a novel RNA in situ hybridization technology (RNAscope) and compare...
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Apolipoprotein a5 genetic polymorphisms in turkish population and the risk of ischemic stroke Şahin, Esra; Adalı, Orhan; Department of Biotechnology (2008) Stroke is the third leading cause of death and the most common cause of disabilities worldwide. Apolipoprotein A5 gene (APO A5), which encodes a 369 amino acid protein called Apolipoprotein AV (apo AV), has several single nucleotide polymorphisms (SNPs) found to be associated with altered triglyceride (TG) levels. Atherosclerosis is a major cause of ischemic stroke and this pathology may be associated with variability of TG levels. The main objective of this study was to investigate the coding region (c.553...
Apolipoprotein A5 polymorphisms in Turkish population: association with serum lipid profile and risk of ischemic stroke CAN DEMİRDÖĞEN, BİRSEN; Sahin, Esra; Ozcelik, Aysun Turkanoglu; Bek, Semai; Demirkaya, Seref; Adalı, Orhan (Springer Science and Business Media LLC, 2012-12-01) Atherosclerosis, a major cause of ischemic stroke, may be associated with variability of triglyceride (TG) levels. Apolipoprotein A5 (APOA5) genetic polymorphisms are associated with altered TG levels. The objective of this study was to investigate the coding region polymorphisms S19W (rs3135506) and G185C (rs2075291) and the promoter region polymorphism -1131T > C (rs662799) of the APOA5 gene as risk factors for ischemic stroke in Turkish population. Study group consisted of 272 ischemic stroke patients an...
Apoptotic Effects of Resveratrol, a Grape Polyphenol, on Imatinib-Sensitive and Resistant K562 Chronic Myeloid Leukemia Cells Can, Geylani; Cakir, Zeynep; Kartal, Melts; Gündüz, Ufuk; BARAN, YUSUF (2012-07-01) Aim: To examine the antiproliferative and apoptotic effects of resveratrol on imatinib-sensitive and imatinib-resistant K562 chronic myeloid leukemia cells. Materials and Methods: Antiproliferative effects of resveratrol were determined by the 3-Bis[2-methoxy-4-nitro-5-sulphophenyl]-2H-tetrazolium-5-carboxanilide inner salt (XTT) cell proliferation assay. Apoptotic effects of resveratrol on sensitive K562 and resistant K562/IMA-3 cells were determined through changes in caspase-3 activity, loss of mitochond...

Citation Formats

Ö. Öngürü, S. Yalçın Azarkan, C. Rosembilt, P. Zhang, S. Kiliç, and U. Gündüz, “Apobec3B expression in drug resistant MCF 7 breast cancer cell lines,” Manchester, İngiltere, 2016, vol. 61, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/85240.