Effects of metformin on olanzapine induced weight gain in wistar rats the change of hypothalamic neurohormones involved in body weight regulation

Date

2015-08-29

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Ak, Mehmet
Kurt, Gizem
Yanık, Tülin

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https://hdl.handle.net/11511/85303

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Effects of metformin on olanzapine induced weight gain in male wistar rats: the change of hypothalamic neurohormones involved in body weight regulation Kurt, Gizem; Yanık, Tülin; Department of Biology (2014) Obesity, resulting from the extreme weight gain, is one of the biggest health problems nowadays because it causes disruption of the metabolism and metabolic problems, including type 2 diabetes mellitus, dyslipidemia and cardiovascular disease. Atypical (second generation) antipsychotic drugs, which are highly in use, have adverse effects including weight gain. Ongoing researches for the treatment of antipsychotics induced-weight gain are present and one of the promising agents is metformin, an anti-diabetic...
Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia Jaros, Julian A.; Rahmoune, Hassan; Wesseling, Hendrik; Leweke, F. Markus; Özcan Kabasakal, Süreyya; Guest, Paul C.; Bahn, Sabine (2015-10-01) Purpose Previous studies have shown that blood serum phosphoproteins are altered in schizophrenia patients in comparison to controls. However, it is not known whether phosphoproteins are also changed in response to treatment with antipsychotics.
Effects of risperidone treatment on the expression of hypothalamic neuropeptide in appetite regulation in Wistar rats Kursungoz, Canan; AK, MEHMET; Yanık, Tülin (2015-01-30) Although the use of atypical antipsychotic drugs has been successful in the treatment of schizophrenia, they can cause some complications in the long-term use, including weight gain. Patients using these drugs tend to disrupt treatment primarily due to side effects. The atypical antipsychotic mechanism of action regulates a number of highly disrupted neurotransmitter pathways in the brains of psychotic patients but may also cause impairment of neurohorrnonal pathways in different brain areas. In this study,...
Effects of carbamazepine on serum parathormone, 25-hydroxyvitamin D, bone specific alkaline phosphatase, C-telopeptide, and osteocalcin levels in healthy rats KIR, HALE MARAL; Garip, Sebnem; ŞAHİN, DENİZ; Oztas, Berrin (2012-11-01) It is still not completely clear whether carbamazepine causes alterations in vitamin D status and in bone metabolism. The objective of this study was to investigate the effects of carbamazepine on serum levels of 25-hydroxyvitamin D and on biomarkers of bone formation and resorption in healthy rats. Levels of calcium, 25- hydroxyvitamin D, parathormone, C-telopeptide, bone specific alkaline phosphatase and osteocalcin were measured in 3 groups of rats consisting of controls (n=10), isotonic saline solution ...
EFFECTS OF IN-VIVO BENZO(A)PYRENE TREATMENT ON LIVER MICROSOMAL MIXED-FUNCTION OXIDASE ACTIVITIES OF GILTHEAD SEABREAM (SPARUS-AURATA) ARINC, E; SEN, A (Elsevier BV, 1994-03-01) Benzo(a)pyrene [B(a)P] treatment of gilthead seabream, 25 mg/kg, i.p. for 5 consecutive days, did not cause any significant changes in ethylmorphine N-demethylase and aniline 4-hydroxylase activities of liver microsomes. The same treatment did not alter the liver microsomal cytochrome b5 content, NADH-cytochrome b5 reductase and NADPH-cytochrome P450 reductase activities. However, benzo(a)pyrene treatment caused a 2-3-fold increase in 7-ethoxyresorufin O-deethylase (7-EROD) activity of gilthead seabream liv...

Citation Formats

M. Ak, G. Kurt, and T. Yanık, “Effects of metformin on olanzapine induced weight gain in wistar rats the change of hypothalamic neurohormones involved in body weight regulation,” 2015, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/85303.