Estrogen signaling and breast cancer



Estrogen-induced upregulation and 3’-UTR shortening of CDC6
Akman, H. Begüm; Erson Bensan, Ayşe Elif; Department of Biology (2013)
Alternative polyadenylation (APA) may cause mRNA 3’-UTR (untranslated region) shortening in different physiological conditions and/or disease states. About half of mammalian genes use alternative cleavage and polyadenylation to generate multiple mRNA isoforms differing in their 3′-UTRs. Consequently, 3’-UTR shortening of mRNAs via APA has important consequences for gene expression. Studies showed that, by preferential use of proximal APA sites and switching to shorter 3’-UTRs, proliferating cells can avoid ...
Estrogen-induced upregulation and 3 '-UTR shortening of CDC6
AKMAN, Begum H.; Can, Tolga; Erson Bensan, Ayşe Elif (2012-11-01)
3'-Untranslated region (UTR) shortening of mRNAs via alternative polyadenylation (APA) has important ramifications for gene expression. By using proximal APA sites and switching to shorter 3'-UTRs, proliferating cells avoid miRNA-mediated repression. Such APA and 3'-UTR shortening events may explain the basis of some of the proto-oncogene activation cases observed in cancer cells. In this study, we investigated whether 17 beta-estradiol (E2), a potent proliferation signal, induces APA and 3'-UTR shortening ...
Estradiol-Estrogen Receptor alpha Mediates the Expression of the CXXC5 Gene through the Estrogen Response Element-Dependent Signaling Pathway
Yasar, Pelin; Ayaz, Gamze; Muyan, Mesut (2016-11-25)
17 beta-estradiol (E2), the primary circulating estrogen hormone, mediates physiological and pathophysiological functions of breast tissue mainly through estrogen receptor alpha (ER alpha). Upon binding to E2, ER alpha modulates the expression of target genes involved in the regulation of cellular proliferation primarily through interactions with specific DNA sequences, estrogen response elements (EREs). Our previous microarray results suggested that E2-ER alpha modulates CXXC5 expression. Because of the pr...
Estradiol releasing hydrogel as a proangiogenic substitute for fat flaps used in urogenital reconstruction
Eke, Gözde; Mangir, Naside; Hasırcı, Nesrin; Chapple, Chris; Hasırcı, Vasıf Nejat; Macneil, Sheila (null; 2017-03-01)
Epidermal growth factor receptor-targeted immunoliposomes for delivery of celecoxib to cancer cells
LIMASALE, Yanuar Dwi Putra; Tezcaner, Ayşen; Özen, Can; Keskin, Dilek; Banerjee, Sreeparna (2015-02-20)
Cyclooxygenase-2 (COX-2) is highly expressed in many different cancers. Therefore, the inhibition of the COX-2 pathway by a selective COX-2 inhibitor, celecoxib (CLX), may be an alternative strategy for cancer prevention and therapy. Liposomal drug delivery systems can be used to increase the therapeutic efficacy of CLX while minimizing its side effects. Previous studies have reported the encapsulation of CLX within the non-targeted long circulating liposomes and functional effect of these formulations agai...
Citation Formats
M. Muyan, “Estrogen signaling and breast cancer,” 2018, Accessed: 00, 2021. [Online]. Available: