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Alternative polyadenylation and its impact on cellular processes
Date
2014-01-01
Author
Akman Tuncer, Hesna Begüm
Erson Bensan, Ayşe Elif
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Impact of mRNA processing and/or modifications has long been associated with gene expression regulation. Accumulating evidence shows alternative polyadenylation (APA), as an mRNA related process, to emerge as a widespread mechanism in gene expression regulation. Through selecting alternate (proximal or distal) polyadenylation signals on the 3'-UTR of pre-mRNAs, APA generates multiple transcript isoforms which may even create proteomic diversity. Depending on the use of proximal or distal polyadenylation sites, 3'-UTR lengths can vary in a tightly controlled manner in a spatial and temporal mode. Therefore, APA and its deregulation with potential consequences are highly relevant to normal and disease states. In this review, in light of recent findings in the literature, mechanism and types of APA and roles of APA in biological processes (i.e. proliferation, development, differentiation, and transformation) are discussed. Similar articles
URI
https://hdl.handle.net/11511/85675
Journal
MICRORNA
DOI
https://doi.org/10.2174/2211536602666131210001152
Collections
Department of Biology, Article
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H. B. Akman Tuncer and A. E. Erson Bensan, “Alternative polyadenylation and its impact on cellular processes,”
MICRORNA
, pp. 2–9, 2014, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/85675.