Synthesis, Anticancer Activity and Docking Studies of New Phenylaminopyrimidine Derivatives

Demirci, Aslı
Durmaz, İrem
Atalay, Rengül
Küçükgüzel, İlkay


Synthesis, Characterization and Evaluation of Cytotoxic Activities of Novel Aziridinyl Phosphonic Acid Derivatives
Khan, Rehan; Ulusan, Sinem; Banerjee, Sreeparna; Doğan, Özdemir (Wiley, 2019-11-01)
New aziridine 2-phosphonic acids were prepared by monohydrolysis of the aziridine 2-phosphonates that were obtained by the modified Gabriel-Cromwell reaction of vinyl phosphonate or alpha-tosylvinyl phosphonate with a primary amine or a chiral amine. The cellular cytotoxicity of these compounds was tested against the HCT-116 colorectal cancer cell lines and the CCD-18Co normal colon fibroblast lines using the MTT assay. Three of the synthesized phosphonic acid derivatives 2e (ethyl hydrogen {(2S)-1-[(1S)-1-...
Synthesis, spectroscopic and electrochemical studies of perylene containing conjugated copolymers
Bayseç, Şebnem; Toppare, Levent Kamil; Yılmaz, Levent; Department of Polymer Science and Technology (2013)
The synthesis , spectroscopic and electrochemical properties of a series of donor-acceptor (DA) type polymers by changing the donor unit (thiophene, dithienopyrrole) polymer backbone were investigated.The synthesized CoP1 and CoP2 were designed to investigate the effect of copolymerization and insertion of perylene tetracarboxylic dimide (PDI) on the structure of benzotriazole (BTz) based polymers. For CoP1 1,7-dibromo-perylene diimide,4,7-dibromo-2-dodecyl-2H-benzo[d][1,2,3]triazole and 2,5 bis(tributylsta...
Synthesis, anticancer activity, toxicity evaluation and molecular docking studies of novel phenylaminopyrimidine-(thio)urea hybrids as potential kinase inhibitors.
Ture, Asli; Kahraman, Deniz Cansen; Atalay, Rengül; Helvacioglu, Sinem; Charehsaz, Mohammad; KÜÇÜKGÜZEL, İLKAY (2019-02-01)
Thirty-two novel urea/thiourea compounds as potential kinase inhibitor were designed, synthesized and evaluated for their cytotoxic activity on breast (MCF7), colon (HCT116) and liver (Huh7) cancer cell lines. Compounds 10, 19 and 30 possessing anticancer activity with IC50 values of 0.9, 0.8 and 1.6 mu M respectively on Huh7 cells were selected for further studies. These hit compounds were tested against liver carcinoma panel. Real time cell electronic sensing assay was used to evaluate the effects of the ...
Synthesis, p-nitrophenolate complexation and competitive anion signaling of novel calixpyrrole dimer
Saki, N; Akkaya, EU (Springer Science and Business Media LLC, 2005-11-01)
A novel dimeric calixpyrrole has been synthesized. The dimer forms stable complexes with p-nitrophenolate ion with a concomitant reduction in extinction coefficient. The chromogenic anion is displaced by the addition of various anions like fluoride and acetate. Effective optical sensing of these anions is accomplished using the calixpyrrole dimer.
Synthesis and biotransformation studies of various appealing synthons for biologically active natural products
Sezen, Bengü; Tanyeli, Cihangir; Department of Chemistry (2000)
Citation Formats
A. Demirci, İ. Durmaz, R. Atalay, and İ. Küçükgüzel, “Synthesis, Anticancer Activity and Docking Studies of New Phenylaminopyrimidine Derivatives,” 2017, Accessed: 00, 2021. [Online]. Available: