Bordetella pertussis’e ait rekombinant dış membran protein Q, demir süperoksit dismutaz ve putatif lipoproteinin immün koruyucu kapasitelerinin değerlendirilmesi

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2017-10-05

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Özcengiz, Gülay

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https://hdl.handle.net/11511/85923

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Assessment of immune protective capacities of the recombinant outer membrane protein q, iron superoxide dismutase and putative lipoprotein from bordetella pertussis Yılmaz, Çiğdem; Özcengiz, Gülay; Department of Biology (2017) Pertussis is a contagious disease which is commonly seen among infants and children and caused by a human pathogen known as Bordetella pertussis. There are currently two vaccine types available against the disease; whole-cell (wP) and acellular pertussis (aP) vaccines. Due to the side effects of wP vaccine, aP vaccines are commonly preferred for vaccination. Despite high vaccination coverage, high incidence rates among adolescents and adults have been reported causing the resurgence of pertussis to be the f...
Immune responses against the recombinant FimX and putative peptidyl-prolyl cis-trans isomerase from Bordetella pertussis Yılmaz, Çiğdem; Özcengiz, Gülay; Department of Biology (2011) Whooping cough (pertussis) is a highly contagious respiratory infection caused by Bordetella pertussis. It becomes widespread among adolescent and adults as well as infants. Although availability of effective pertussis vaccines seems to decrease the incidence of the disease, B. pertussis circulation in population has not been eliminated. It is thought that the antigenic drifts in major protective antigens and continued circulation of B. pertussis strains will result in gradual loss of the efficacy of the cu...
Towards whole cell immunoproteome and subproteomes of bordetella pertussis Tefon, Burcu Emine; Özcengiz, Gülay; Department of Biology (2012) Bordetella pertussis is a gram-negative, human pathogen and etiologic agent of whooping cough (pertussis), a highly contagious, acute respiratory illness. In this study, the analysis of whole immunproteome and subproteomes of this microorganism was performed. The soluble cytoplasmic proteomes of B. pertussis Tohama I strain and a local isolate Saadet were separated by 2DE. By Western blot analysis, we identified 25 immunogenic proteins of three categories. In the first group, there were well-known proteins ...
Bordetella pertussis Tohama I ve Saadet suşuna ait PPIase, POMP ve FIMX genlerinin klonlanması Özcengiz, Gülay (2009-12-13)
Identification of the new immunogenic proteins of bordetella pertussis by immunoproteomics Altındiş, Emrah; Özcengiz, Gülay; Department of Biotechnology (2007) The genus Bordetella contains several pathogenic species generally associated with upper respiratory tract infections in warm-blooded animals. Bordetella pertussis is the etiologic agent of whooping cough. Whooping cough is presently one of the ten most common causes of death from infectious diseases and reported by the World Health Organisation (WHO) to cause 50 million cases and 350000 deaths worldwide per year, mainly among unvaccinated individuals in poor countries. The term proteome, in analogy to the ...

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G. Özcengiz, “Bordetella pertussis’e ait rekombinant dış membran protein Q, demir süperoksit dismutaz ve putatif lipoproteinin immün koruyucu kapasitelerinin değerlendirilmesi,” 2017, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/85923.