Metabolic engineering of aspartate pathway for increased production of cephamycin C in Streptomyces clavuligerus

2009-09-27
Özcengiz, Gülay
Show full item record
57
views
0
downloads
https://hdl.handle.net/11511/86041
Unverified, Conference / Seminar

Suggestions

Metabolic engineering of aromatic group amino acid pathway in Bacillus subtilis for L-phenylalanine production
Ozcelik, IS; Çalık, Pınar; Calik, G; Ozdamar, TH (Elsevier BV, 2004-11-01)
Metabolic control sites in the aromatic group amino acid pathway (AAAP) of Bacillus subtilis for L-Phenylalanine (Phe) overproduction were determined; and aiming pathway flux amplification, by cloning the flux controlling gene aroH to a multi-copy plasmid, the impact of single gene cloning on pathway flux distributions were investigated. The branch-point metabolites E4P and PEP+E4P supplied in vitro, enhanced Phe production and well defined perturbations were achieved on the AAAP reactions. The intracellula...
Metabolic engineering of L-phenylalanine pathway in Bacillus subtilis
Demirci, Y; Çalık, Pınar; Calik, G; Ozdamar, TH (2005-08-01)
Metabolic engineering with a novel promoter in Pichia pastoris for recombinant human growth hormone production: effects of oxygen transfer conditions
Kalender, Özge; Çalık, Pınar; Özdamar, Tunçer; Department of Chemical Engineering (2018)
The objectives of this thesis are investigation of, i) the effects of oxygen transfer conditions on recombinant protein production in Pichia pastoris strains designed with novel naturally occuring pyruvate kinase (PYK) promoter (PPYK) which is a potential promoter for recombinant protein production under low to moderate oxygen transfer conditions, and ii) influences of engineering with single- and multi- copy genes, in fed-batch fermentation processes. Production of recombinant human growth hormone (rhGH) b...
Metabolic flux analyses for serine alkaline protease production
Çalık, Pınar; Ozdamar, TH (2000-12-01)
The intracellular metabolic fluxes through the central carbon pathways in Bacillus licheniformis in serine alkaline protease (SAP) production were calculated to predict the potential strategies for increasing the performance of the bacilli, by using two optimization approaches, i.e. the theoretical data-based (TDA) and the theoretical data-based capacity (TDC) analyses based on respectively minimum in-vivo SAP accumulation rate and maximum SAP synthesis rate assumptions, at low-, medium, and high-oxygen tra...
Metabolic engineering design of an extracellular hGH synthesis system
Senturk, B; Çalık, Pınar; Calik, G; Ozdamar, TH (2005-08-01)
Citation Formats
G. Özcengiz, “Metabolic engineering of aspartate pathway for increased production of cephamycin C in Streptomyces clavuligerus,” 2009, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/86041.
METU IIS - Integrated Information Service open@metu.edu.tr