In Vitro and In Vivo Toxicity Analyses of Bare and Chitosan Coated MNPs

Gözde, Ünsoy
Yalçın Azarkan, Serap
Rouhollah, Khodadust
Pelin, Mutlu
Çelik, T
Macit, E
K G, Ulusoy
Önder, Öngörü
Gündüz, Ufuk


In vitro and in vivo evaluation of the effects of demineralized bone matrix or calcium sulfate addition to polycaprolactone-bioglass composites
ERDEMLİ, ÖZGE; Captug, O.; Bilgili, H.; ORHAN, DİCLEHAN; Tezcaner, Ayşen; Keskin, Dilek (Springer Science and Business Media LLC, 2010-01-01)
The objective of this study was to improve the efficacy of polycaprolactone/bioglass (PCL/BG) bone substitute using demineralized bone matrix (DBM) or calcium sulfate (CS) as a third component. Composite discs involving either DBM or CS were prepared by compression moulding. Bioactivity of discs was evaluated by energy dispersive X-ray spectroscopy (ESCA) and scanning electron microscopy (SEM) following simulated body fluid incubation. The closest Calcium/Phosphate ratio to that of hydroxyl carbonate apatit...
In vitro and in vivo evaluation of doxycycline-chondroitin sulfate/PCLmicrospheres for intraarticular treatment of osteoarthritis
AYDIN, Ozlem; KORKUSUZ, FEZA; KORKUSUZ, PETEK; Tezcaner, Ayşen; BİLGİÇ, ELİF; Yaprakci, Volkan; Keskin, Dilek (2015-08-01)
Osteoarthritis (OA) is a degenerative joint disease, which has no complete treatment with medication yet. Intraarticular hyaluronan (HA) injection can decrease pain and modify the natural course of OA. This study was designed to provide long term delivery of an MMP (matrix-metalloproteinase) inhibitor agent-doxycycline, together with matrix regenerative agent-chondroitin sulfate for treating OA which progress with matrix degenerations. Doxycycline (D) and doxycycline-chondroitin sulfate (D-CS) loaded poly--...
In vitro bioactivity investigation of alkali treated Ti6Al7Nb alloy foams
Butev, Ezgi; ESEN, ZİYA; Bor, Sakir (2015-02-01)
Biocompatible Ti6Al7Nb alloy foams with 70% porosity manufactured by space holder method were activated via alkali treatment using 5 M NaOH solution at 60 degrees C. The interconnected pore structures enabled formation of homogenous sodium rich coating on the foam surfaces by allowing penetration of alkali solution throughout the pores which had average size of 200 mu m. The resulted coating layer having 500 nm thickness exhibited porous network morphology with 100 nm pore size. On the other hand, heat trea...
In vitro digestibility of rare sugar (D-allulose) added pectin-soy protein gels
Ateş, Elif Gökçen; Ozvural, Emin Burcin; Oztop, Mecit H. (2021-04-01)
Confectionery gels are known to be high-caloric products due their high sugar content. Changing their formulations by substituting the sugar with alternative natural sweeteners and functionalising them, the addition of proteins has gained attention. Understanding the rate of digestion of these products is also important for selecting the appropriate formulation. In this study, in vitro gastric digestion behaviour of the gels formulated with D-allulose, a low-calorie rare sugar, soy protein isolate (SPI) (1%...
In vitro cytotoxicity and genotoxicity of metallic and polymeric materials
Gulce, S.; Gurhan, S. I.; Hasırcı, Nesrin; Endogan, T. (2006-06-01)
Citation Formats
Ü. Gözde et al., “In Vitro and In Vivo Toxicity Analyses of Bare and Chitosan Coated MNPs,” 2015, Accessed: 00, 2021. [Online]. Available: