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A digital microfluidic interface between solid-phase microextraction and liquid chromatography–mass spectrometry for determination of free concentration of steroids in urine
Date
2016-07-03
Author
Boyacı, Ezel
Kim, J.
Seale, B.
Barrera-arbelaez, B.
Pawliszyn, Janusz
Wheeler, Aaron
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https://hdl.handle.net/11511/88411
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We introduce a method to couple solid-phase microextraction (SPME) with HPLC-MS using digital microfluidics (DMF). In the new system, SPME fibers are used to extract analytes from complex sample solutions, after which the analytes are desorbed into solvent droplets in a DMF device. The open geometry of DMF allows straightforward insertion of SPME fibers without requiring a complicated interface, and automated droplet manipulation enables multiplexed processing of the fibers. In contrast to other multiplexed...
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E. Boyacı, J. Kim, B. Seale, B. Barrera-arbelaez, J. Pawliszyn, and A. Wheeler, “A digital microfluidic interface between solid-phase microextraction and liquid chromatography–mass spectrometry for determination of free concentration of steroids in urine,” 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/88411.