In vitro validation of drug-target interactions revealed in silico by Comprehensive Resource of Biomedical Relations with Network Representations and Deep Learning (CROssBAR) in HCC

Nalbat, Esra
Martin, Maria Jesus
Cetin-Atalay, Rengul
Atalay, Mehmet Volkan


In vitro investigation and biomechanical modeling of the effects of PLF-68 on osteoarthritis in a three-dimensional model
Kavas, Aysegul; Ozdemir, Mustafa; Gürses, Senih; Keskin, Dilek; Tezcaner, Ayşen (2011-10-01)
In this study, it was hypothesized that Pluronic F-68 (PLF-68) increases matrix synthesis of osteoarthritis (OA) chondrocytes in addition to its well-documented cell survival effect. To test this hypothesis, rat articular chondrocytes were embedded in agarose discs and were exposed to 5-azacytidine (Aza-C) to induce OA-like alterations. Chondrocytes were then treated with PLF-68 (8 and 12 mg/ml) for 10 days. Aza-C-exposed and PLF-68-untreated chondrocytes and Aza-C-unexposed and PLF-68-untreated chondrocyte...
In vitro evaluation of PLLA/PBS sponges as a promising biodegradable scaffold for neural tissue engineering
Kanneci Altinisik, Irem Ayse; Kök, Fatma Neşe; Yucel, Deniz; KÖSE, GAMZE (The Scientific and Technological Research Council of Turkey, 2017-01-01)
In tissue engineering, the use of poly-L-lactic acid (PLLA)/polybutylene succinate (PBS) blend for the construction of scaffold is very limited. Moreover, polymeric sponges fabricated from PLLA/PBS have not been studied for neural tissue engineering. In the present study, the potential of the utility of PLLA/PBS polymeric sponges seeded with Schwann cells was investigated. PLLA and PBS were blended in order to increase the processability and tune the crystallinity, porosity, and degradation rate of the resu...
In vitro experimental evaluation of the effect of different lining materials and alloy shape on fracture resistance of class II Amalgam restorations
Eminkahyagil, Neslihan; Orçan, Yusuf; Gökalp, Saadet; Department of Engineering Sciences (1999)
In vitro performance of a nanobiocomposite scaffold containing boron-modified bioactive glass nanoparticles for dentin regeneration
Rad, Reza Moonesi; Pazarçeviren, Ahmet Engin; Akguen, Elif Ece; Evis, Zafer; Keskin, Dilek; Sahin, Sila; Tezcaner, Ayşen (SAGE Publications, 2019-01-01)
Every year, many dental restoration methods are carried out in the world and most of them do not succeed. High cost of these restorations and rejection possibility of the implants are main drawbacks. For this reason, a regenerative approach for repairing the damaged dentin-pulp complex or generating a new tissue is needed. In this study, the potential of three-dimensional cellulose acetate/oxidized pullulan/gelatin-based dentin-like constructs containing 10 or 20% bioactive glass nanoparticles was studied t...
In vivo verification of different hip joint center estimation methods in gait analysis for healthy subjects
Yousefi, Abdollah; Tönük, Ergin; Kentel, Behzat Bahadır; Department of Mechanical Engineering (2014)
Hip joint is one of the most stable joints in human body. It has intrinsic stability provided by its relatively rigid ball and socket configuration. The hip joint also has a wide range of motion, which allows normal locomotion and daily activities. Location of hip joint center (HJC) is an important parameter in gait analysis, biomechanical and clinical research laboratories to calculate human lower extremity kinematics and kinetics. There exists different methods to determine HJC. Although invasive methods ...
Citation Formats
E. Nalbat, T. DOĞAN, M. J. Martin, R. Cetin-Atalay, and M. V. Atalay, “In vitro validation of drug-target interactions revealed in silico by Comprehensive Resource of Biomedical Relations with Network Representations and Deep Learning (CROssBAR) in HCC,” ELECTR NETWORK, 2020, vol. 80, Accessed: 00, 2021. [Online]. Available: