A Role for Notch Signalling in Breast Cancer and Endocrine Resistancesssss

Date

2016-01-01

Author

Acar, Ahmet
Simoes, Bruno M.
Clarke, Robert B.
Brennan, Keith

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Over the past decade, there has been growing interest in the Notch signalling pathway within the breast cancer field. This interest stemmed initially from the observation that Notch signalling is aberrantly activated in breast cancer and its effects on various cellular processes including proliferation, apoptosis, and cancer stem cell activity. However more recently, elevated Notch signalling has been correlated with therapy resistance in oestrogen receptor-positive breast cancer. As a result, inhibiting Notch signalling with therapeutic agents is being explored as a promising treatment option for breast cancer patients.

URI

https://hdl.handle.net/11511/89498

Journal

STEM CELLS INTERNATIONAL

DOI

https://doi.org/10.1155/2016/2498764

Collections

Department of Biology, Article

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Citation Formats

A. Acar, B. M. Simoes, R. B. Clarke, and K. Brennan, “A Role for Notch Signalling in Breast Cancer and Endocrine Resistancesssss,” STEM CELLS INTERNATIONAL, pp. 0–0, 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/89498.