Ahmet Acar

E-mail

acara@metu.edu.tr

Department

Department of Biology

ORCID

0000-0002-2478-8029

Scopus Author ID

57212498766

Web of Science Researcher ID

ABI-3298-2020

Investigation of potential KRASG12D inhibitors: a comparative study between MRTX1133 and natural compounds via computational structural biology approaches. Bostancioglu, Safiye Merve; Acar, Ahmet (2025-07-12) Objective The RAS family, comprising KRAS, NRAS, and HRAS, plays a pivotal role in oncogenesis, dynamically regulating cellular processes through intricate cycling between active and inactive states. Despite recent advance...
Endoglin mediates the tumor- and metastasis-promoting traits of stromal myofibroblasts in human breast carcinomas. Okubo, Shoki; Mezawa, Yoshihiro; Wang, Zixu; Acar, Ahmet; Ito, Yasuhiko; Takano, Atsushi; Miyagi, Yohei; Yokose, Tomoyuki; Toshinari, Yamashita; Daigo, Yataro; Shirakihara, Takuya; Orimo, Akira (2025-07-11)
Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm. Oliveira, Erica A; Milite, Salvatore; Fernandez-Mateos, Javier; Cresswell, George D; Yara-Romero, Erika; Vlachogiannis, Georgios; Chen, Bingjie; James, Chela T; Patruno, Lucrezia; Ascolani, Gianluca; Acar, Ahmet; Heide, Timon; Spiteri, Inmaculada; Graudenzi, Alex; Caravagna, Giulio; Bertotti, Andrea; Graham, Trevor A; Magnani, Luca; Valeri, Nicola; Sottoriva, Andrea (2025-06-11)
Holistic precision wellness: Paving the way for next-generation precision medicine (ngPM) with AI, biomedical informatics, and clinical medicine Mohammed, Sawsan G. A. A.; Qoronfleh, M. Walid; Acar, Ahmet; Al-Dewik, Nader I. (2025-04-01) A “quiet revolution” in medicine has been taking place over the past two decades. There are two converging dynamic forces that have propelled precision medicine to the limelight, garnering wide public attention. The first ...
Benchmarking long-read structural variant calling tools and combinations for detecting somatic variants in cancer genomes. Aydin, Safa Kerem; Yilmaz, Kubra Celikbas; Acar, Ahmet (2025-03-13) Cancer genomes have a complicated landscape of mutations, including large-scale rearrangements known as structural variants (SVs). These SVs can disrupt genes or regulatory elements, playing a critical role in cancer devel...
Colorectal cancer tumor grade segmentation: A new dataset and baseline results Arslan, Duygu; Sehlaver, Sina; Guder, Erce; Temena, Mehmet Arda; Bahcekapili, Alper; Ozdemir, Umut; Turkay, Duriye Ozer; Guner, Gunes; Guresci, Servet; SÖKMENSÜER, CENK; Akbaş, Emre; Acar, Ahmet (2025-02-28) Routine pathology assessment for the tumor grading is currently performed under the microscope by experienced pathologists which might be prone to interpersonal variability and requiring years of experience. Over the past ...
Patient-Derived Organoids: Past, Present, and Future Acar, Ahmet (Springer, London/Berlin , 2024-09-01)
Exploiting Matrix Stiffness to Overcome Drug Resistance Aydin, Hakan Berk; Özçelikkale, Altuğ; Acar, Ahmet (2024-07-05) Drug resistance is arguably one of the biggest challenges facing cancer research today. Understanding the underlying mechanisms of drug resistance in tumor progression and metastasis are essential in developing better trea...
Optimizing cancer therapy: a review of the multifaceted effects of metronomic chemotherapy Basar, Oyku Yagmur; Mohammed, Sawsan; Qoronfleh, M. Walid; Acar, Ahmet (2024-05-01)
Tumor-Microenvironment-on-Chip Platform for Assessing Drug Response in 3D Dynamic Culture Aydin, Hakan Berk; Moon, Hye-Ran; Han, Bumsoo; Ozcelikkale, Altug; Acar, Ahmet (Springer Nature, 2024-02-01)

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