Burçak Otlu Sarıtaş

E-mail

burcako@metu.edu.tr

Department

Graduate School of Informatics

Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor Islam, S.M. Ashiqul; et. al. (2022-11-09) Mutational signature analysis is commonly performed in cancer genomic studies. Here, we present SigProfilerExtractor, an automated tool for de novo extraction of mutational signatures, and benchmark it against another 13 b...
HIBIT Proceedings 2022 Aydın Son, Yeşim; Karahan, Arzu; Otlu Sarıtaş, Burçak (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) ABOUT HIBIT The International Symposium on Health Informatics and Bioinformatics (HIBIT), first held in 2005, aims to bring together academics, researchers, and practitioners who work in these popular and fulfilling are...
Genomic and evolutionary classification of lung cancer in never smokers Zhang, Tongwu; et. al. (2021-09-01) Lung cancer in never smokers (LCINS) is a common cause of cancer mortality but its genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing of 232 LCINS showed 3 subtypes defined by copy number...
The genomic and epigenomic evolutionary history of papillary renal cell carcinomas Zhu, Bin; et. al. (2020-06-01) Intratumor heterogeneity (ITH) and tumor evolution have been well described for clear cell renal cell carcinomas (ccRCC), but they are less studied for other kidney cancer subtypes. Here we investigate ITH and clonal evolu...
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis Petljak, Mia; et. al. (2019-03-01) Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity of t...

Citation Formats