Perinatal exposure to maternal obesity: Lasting cardiometabolic impact on offspring

Kışlal, Sezen
Edlow, Andrea G.
Evidence from epidemiological, clinical, and animal model studies clearly demonstrates that prenatal and lactational maternal obesity and high-fat diet consumption are associated with cardiometabolic morbidity in offspring. Fetal and offspring sex may be an important effect modifier. Adverse offspring cardiometabolic outcomes observed in the setting of maternal obesity include an increased risk for obesity, features of metabolic syndrome (hypertension, hyperglycemia and insulin resistance, hyperlipidemia, increased adiposity), and non-alcoholic fatty liver disease. This review article synthesizes human and animal data linking maternal obesity and high-fat diet consumption in pregnancy and lactation to adverse cardiometabolic outcomes in offspring. We review key mechanisms underlying skeletal muscle, adipose tissue, pancreatic, liver, and central brain reward programming in obesity-exposed offspring, and how such malprogramming contributes to offspring cardiometabolic morbidity.


Fetal brain and placental programming in maternal obesity: A review of human and animal model studies
Shook, Lydia L.; Kışlal, Sezen; Edlow, Andrea G. (2020-08-01)
Both human epidemiologic and animal model studies demonstrate that prenatal and lactational exposure to maternal obesity and high-fat diet are associated with adverse neurodevelopmental outcomes in offspring. Neurodevelopmental outcomes described in offspring of obese women include cognitive impairment, autism spectrum disorder (ASD), attention deficit hyperactivity disorder, anxiety and depression, disordered eating, and propensity for reward-driven behavior, among others. This review synthesizes human and...
Mismatch between obesogenic intrauterine environment and low-fat postnatal diet may confer offspring metabolic advantage
Kışlal, Sezen; Maesner, Claire; Edlow, Andrea G. (2021-08-01)
Objective: Mismatch between a depleted intrauterine environment and a substrate-rich postnatal environment confers an increased risk of offspring obesity and metabolic syndrome. Maternal diet-induced obesity (MATOB) is associated with the same outcomes. These experiments tested the hypothesis that a mismatch between a nutrient-rich intrauterine environment and a low-fat postnatal environment would ameliorate offspring metabolic morbidity.
Selective Fetal Growth Restriction in Dichorionic Twin Pregnancies: Diagnosis, Natural History, and Perinatal Outcome
Antonakopoulos, Nikolaos; Pateisky, Petra; Liu, Becky; Kalafat, Erkan; Thilaganathan, Baskaran; Khalil, Asma (MDPI AG, 2020-5-9)
This study aims to evaluate the natural history, disease progression, and outcomes in dichorionic twins with selective fetal growth restriction (sFGR) according to different diagnostic criteria and time of onset. Dichorionic twins seen from the first trimester were included. sFGR was classified according to the Delphi consensus, and was compared to the outcomes of those classified by the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) diagnostic criteria. Early sFGR occurred before ...
Determinants of Health Behaviors and Obesity in Turkey
Tansel, Aysd; Karaoglan, Deniz (2019-07-01)
The purpose of this paper is to examine the determinants of health behaviors and obesity with an emphasis on education in Turkey. We use Health Survey of Turkish Statistical Institute for the years 2008, 2010 and 2012. The health behaviors considered are smoking, alcohol consumption, fruit and vegetable consumption, and exercise. We consider both the years of schooling and the different levels of education in order to better understand the association between education and health. We find that education is ...
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Bilim, İbrahim; Öztekin, Ceren; Department of Elementary Science and Mathematics Education (2015)
This study was conducted in attempt to integrate a number of cognitive and motivational factors in healthy eating domain and to develop a structural model that might explain young students’ healthy eating intentions and behaviors. Founded on the theory of planned behavior framework, the current study explored the interrelationships among students’ behavioral beliefs, control beliefs, normative beliefs, and attitudes toward behavior, subjective norms, perceived behavioral control (PBC), intentions, personal ...
Citation Formats
S. Kışlal and A. G. Edlow, “Perinatal exposure to maternal obesity: Lasting cardiometabolic impact on offspring,” PRENATAL DIAGNOSIS, vol. 40, no. 9, pp. 1109–1125, 2020, Accessed: 00, 2021. [Online]. Available: