Perinatal exposure to maternal obesity: Lasting cardiometabolic impact on offspring

Date

2020-08-01

Author

Kışlal, Sezen
Edlow, Andrea G.

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Evidence from epidemiological, clinical, and animal model studies clearly demonstrates that prenatal and lactational maternal obesity and high-fat diet consumption are associated with cardiometabolic morbidity in offspring. Fetal and offspring sex may be an important effect modifier. Adverse offspring cardiometabolic outcomes observed in the setting of maternal obesity include an increased risk for obesity, features of metabolic syndrome (hypertension, hyperglycemia and insulin resistance, hyperlipidemia, increased adiposity), and non-alcoholic fatty liver disease. This review article synthesizes human and animal data linking maternal obesity and high-fat diet consumption in pregnancy and lactation to adverse cardiometabolic outcomes in offspring. We review key mechanisms underlying skeletal muscle, adipose tissue, pancreatic, liver, and central brain reward programming in obesity-exposed offspring, and how such malprogramming contributes to offspring cardiometabolic morbidity.

URI

https://hdl.handle.net/11511/93658

Journal

PRENATAL DIAGNOSIS

DOI

https://doi.org/10.1002/pd.5784

Collections

Department of Psychology, Article

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Citation Formats

S. Kışlal and A. G. Edlow, “Perinatal exposure to maternal obesity: Lasting cardiometabolic impact on offspring,” PRENATAL DIAGNOSIS, vol. 40, no. 9, pp. 1109–1125, 2020, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/93658.