Synthesis Of Dihydropyrimidine Derivatives With L-/T-Type Calcium Channel Blocking Activities

Gündüz, Miyase Gözde
Dengiz, Çağatay
Sun, Huang
Zamponi, Gerald


Synthesis of 2-aziridinyl phosphonates by modified Gabriel-Cromwell reaction and their antibacterial activities
Doğan, Özdemir; Gözen, Ayşe Gül (Elsevier BV, 2011-06-01)
A set of new aziridinyl phosphonates (4a-g) were synthesized by using the Gabriel-Cromwell reaction and its modified version developed in this study and their structures confirmed by HRMS, IR. and NMR spectra. All the compounds were screened for their antibacterial activity. They all showed comparable moderate to good growth inhibitory activity in reference to ampicillin and streptomycin. (C) 2011 Elsevier Masson SAS. All rights reserved.
Synthesis of bicyclo[2.2.2]octane-2,3,5,6,7,8 hexols (Bishomoinositols) as glycosidase inhibitors
Baran, Arif; Guenel, Aslihan; Balcı, Metin (American Chemical Society (ACS), 2008-06-20)
For the construction of the bicyclo[2.2.2] octane skeleton, 2,2-dimethyl-3a,7a-dihydro-1,3-benzodioxole was reacted with vinylene carbonate to give two isomeric cycloadditon products having the bicyclo[2.2.2]octane skeleton. Hydrolysis of the ketal ring and the opening of the carbonate functionality, followed by hydroxylation of the remaining double bond resulted in the formation of a symmetrical hexol. Epoxidation of the double bond in the cycloaddition products and the subsequent ring-opening reactions pr...
Synthesis of 1,2,3,5- tetrasubstituted pyrrole derivatives via 5-exo-dig type cyclization and stereoselective functionalisation of ferrocene derivatives
Kayalar, Metin; Demir, Ayhan Sıtkı; Department of Chemistry (2005)
A convenient and new method for the synthesis of 1,2,3,5-tetrasubstituted pyrrole derivatives starting from 1,3,-dicarbonyl compounds through acid catalyzed cyclization reaction is described. Alkylation of 1,3-dicarbonyl compound with propargyl bromide followed by one step cyclization with the introduction of primary amines in the presence of catalytic amount of triflouroacetic acid (TFA) affords the corresponding pyrrole derivatives in high yields. The investigations on the studies of developing a new meth...
Synthesis of heterocyclic molecules from N-propargylic β- enaminones
Zora, Metin (null; 2019-03-17)
Recently, pyrroles, pyridines, 1,4-oxazepines and 1,4-thiazepines have emerged as valuable compounds in the design and synthesis of novel biologically active agents that display prominent medicinal activities. Therefore, development of new efficient methods for their synthesis is highly desired since they can furnish molecules with pronounced or distinct biological activities. Recently, cyclization of functionally substituted alkynes has been recognized as a valuable tool to synthesize a variety of importan...
Synthesis of triazene-substituted homoconjugated push-pull chromophores by formal [2 + 2] cycloadditions
Erden, Kübra; Dengiz, Çağatay (Elsevier BV, 2019-07-25)
1-(4-Ethynylphenyl)-3,3-dialkyltriaz-1-enes, well-known building blocks for branched dendrimer syntheses, were utilized as a new type of electron-donor component in formal [2 + 2] cycloadditions. The click-type, atom-economic reactions proceed efficiently under ambient conditions without any catalyst. The resulting products are structurally interesting push-pull chromophores and were investigated in the context of optoelectronic properties using UV/Vis spectroscopy, NMR studies, and computational chemistry
Citation Formats
M. G. Gündüz, Ç. Dengiz, H. Sun, and G. Zamponi, “Synthesis Of Dihydropyrimidine Derivatives With L-/T-Type Calcium Channel Blocking Activities,” presented at the 13th International Symposium on Pharmaceutical Sciences, Ankara, Türkiye, 2021, Accessed: 00, 2021. [Online]. Available: