Synthesis Of Dihydropyrimidine Derivatives With L-/T-Type Calcium Channel Blocking Activities

Date

2021-06-22

Author

Gündüz, Miyase Gözde
Dengiz, Çağatay
Sun, Huang
Zamponi, Gerald

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

132
views

0
downloads

URI

https://hdl.handle.net/11511/93858

Conference Name

13th International Symposium on Pharmaceutical Sciences

Collections

Department of Chemistry, Conference / Seminar

Suggestions

OpenMETU
Core

Synthesis of 2-aziridinyl phosphonates by modified Gabriel-Cromwell reaction and their antibacterial activities Doğan, Özdemir; Gözen, Ayşe Gül (Elsevier BV, 2011-06-01) A set of new aziridinyl phosphonates (4a-g) were synthesized by using the Gabriel-Cromwell reaction and its modified version developed in this study and their structures confirmed by HRMS, IR. and NMR spectra. All the compounds were screened for their antibacterial activity. They all showed comparable moderate to good growth inhibitory activity in reference to ampicillin and streptomycin. (C) 2011 Elsevier Masson SAS. All rights reserved.
Synthesis of bicyclo[2.2.2]octane-2,3,5,6,7,8 hexols (Bishomoinositols) as glycosidase inhibitors Baran, Arif; Guenel, Aslihan; Balcı, Metin (American Chemical Society (ACS), 2008-06-20) For the construction of the bicyclo[2.2.2] octane skeleton, 2,2-dimethyl-3a,7a-dihydro-1,3-benzodioxole was reacted with vinylene carbonate to give two isomeric cycloadditon products having the bicyclo[2.2.2]octane skeleton. Hydrolysis of the ketal ring and the opening of the carbonate functionality, followed by hydroxylation of the remaining double bond resulted in the formation of a symmetrical hexol. Epoxidation of the double bond in the cycloaddition products and the subsequent ring-opening reactions pr...
Synthesis of 1,2,3,5- tetrasubstituted pyrrole derivatives via 5-exo-dig type cyclization and stereoselective functionalisation of ferrocene derivatives Kayalar, Metin; Demir, Ayhan Sıtkı; Department of Chemistry (2005) A convenient and new method for the synthesis of 1,2,3,5-tetrasubstituted pyrrole derivatives starting from 1,3,-dicarbonyl compounds through acid catalyzed cyclization reaction is described. Alkylation of 1,3-dicarbonyl compound with propargyl bromide followed by one step cyclization with the introduction of primary amines in the presence of catalytic amount of triflouroacetic acid (TFA) affords the corresponding pyrrole derivatives in high yields. The investigations on the studies of developing a new meth...
Synthesis of heterocyclic molecules from N-propargylic β- enaminones Zora, Metin (null; 2019-03-17) Recently, pyrroles, pyridines, 1,4-oxazepines and 1,4-thiazepines have emerged as valuable compounds in the design and synthesis of novel biologically active agents that display prominent medicinal activities. Therefore, development of new efficient methods for their synthesis is highly desired since they can furnish molecules with pronounced or distinct biological activities. Recently, cyclization of functionally substituted alkynes has been recognized as a valuable tool to synthesize a variety of importan...
Synthesis of Cyano-Substituted Diaryltetracenes from Tetraaryl[3]cumulenes Gawel, Przemyslaw; Dengiz, Çağatay; Finke, Aaron D.; Trapp, Nils; Boudon, Corinne; Gisselbrecht, Jean-Paul; Diederich, Francois (2014-09-11)

Citation Formats

M. G. Gündüz, Ç. Dengiz, H. Sun, and G. Zamponi, “Synthesis Of Dihydropyrimidine Derivatives With L-/T-Type Calcium Channel Blocking Activities,” presented at the 13th International Symposium on Pharmaceutical Sciences, Ankara, Türkiye, 2021, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/93858.