Human-Induced Pluripotent Stem Cell-Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases.

Advances in experimental medicine and biology


Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: a synchrotron x-ray scattering study.
Choi, MC; Raviv, U; Miller, HP; Gaylord, MR; Kiriş, Erkan; Ventimiglia, D; Needleman, DJ; Kim, MW; Wilson, L; Feinstein, SC; Safinya, CR (2009-07-22)
Microtubules (MTs), a major component of the eukaryotic cytoskeleton, are 25 nm protein nanotubes with walls comprised of assembled protofilaments built from ab heterodimeric tubulin. In neural cells, different isoforms of the microtubule-associated-protein (MAP) tau regulate tubulin assembly and MT stability. Using synchrotron small angle x-ray scattering (SAXS), we have examined the effects of all six naturally occurring central nervous system tau isoforms on the assembly structure of taxol-stabilized MTs...
Human growth hormone production by metabolically engineered b. subtilis : feeding strategy development
Gökbudak, Burcu; Çalık, Pınar; Özdamar, Tunçer H.; Department of Chemical Engineering (2013)
In this study, the aim is to develop an effective feeding strategy for therapeutically important protein, recombinant human growth hormone (rhGH) production by Bacillus subtilis scoC knockout (scoC-) strain carrying pMK4::pre(subC)::hGH plasmid. In the first part of the research program, laboratory scale air filtered shake bioreactor experiments were conducted to optimize the production conditions. Thereafter, semi-batch production processes at pilot scale bioreactor system were performed by designing expon...
Human behavior understanding through 3D data
Akdağ, Erkut; Halıcı, Uğur; Department of Electrical and Electronics Engineering (2015)
In the human action recognition area, so far 2D action recognition has been studied extensively. Recently some studies, understanding human actions in 3D is emerging due to development of devices collecting 3D data. In this thesis, a new human behavior recognition method, that we call silhouette flows, is proposed for 3D data sequences of depth map. The method proposed in this thesis constitutes two steps, which are the feature extraction and classification. In feature extraction part, motion features are e...
Human Gut Commensal Membrane Vesicles Modulate Inflammation by Generating M2-like Macrophages and Myeloid-Derived Suppressor Cells
Bulut, Esin Alpdundar; Kocabas, Banu Bayyurt; Yazar, Volkan; Aykut, Gamze; GÜLER, ÜLKÜ; SALİH, BEKİR; Yilmaz, Naz Surucu; Ayanoğlu, İhsan Cihan; Polat, Muammer Merve; AKÇALI, KAMİL CAN; GÜRSEL, İHSAN; Gürsel, Mayda (2020-11-01)
Immunomodulatory commensal bacteria modify host immunity through delivery of regulatory microbial-derived products to host cells. Extracellular membrane vesicles (MVs) secreted from symbiont commensals represent one such transport mechanism. How MVs exert their anti-inflammatory effects or whether their tolerance-inducing potential can be used for therapeutic purposes remains poorly defined. In this study, we show that MVs isolated from the human lactic acid commensal bacteria Pediococcus pentosaceus suppre...
Mouse Embryonic Stem Cell Culture in Serum-Containing or 2i Conditions.
Balbasi, Emre; Guven, Gozde; Terzi Çizmecioğlu, Nihal (2021-10-19)
Citation Formats
E. Kiriş, “Human-Induced Pluripotent Stem Cell-Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases.,” Advances in experimental medicine and biology, 2021, Accessed: 00, 2021. [Online]. Available: