Complete chemical and structural characterization of selenium-incorporated hydroxyapatite

2022-01-01
Alkan, Baris
Durucan, Caner
Hydroxyapatite (HAp) has long been used as synthetic bone tissue replacement material. Recent advances in this area have led to development of dual-functional bioceramics exhibiting high biocompability/osteoconductivity together with the therapeutic effect. Selenium, in that respect, is an effective therapeutic agent with promising antioxidant activity and anticancer effects. In this study, selenium-incorporated hydroxyapatite (HAp:Se) particles have been synthesized by modified aqueous precipitation method using calcium (Ca(NO3)(2)center dot 4H(2)O) and phosphate ((NH4)(2)HPO4) salts and sodium selenite (Na2SeO3). The effects of selenium incorporation and post-synthesis calcination treatment (900-1100 degrees C) on physical, chemical properties and crystal structure of resultant HAp powders have been investigated. Complete chemical identification was performed with spectroscopical analyses including Fourier transform infrared and x-ray photoelectron spectroscopy to elucidate the mechanism and chemical nature of selenium incorporation in HAp. Meanwhile, detailed x-ray diffraction studies by Rietveld refinement have conducted to explain changes in the HAp crystal structure upon selenium incorporation.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

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Citation Formats
B. Alkan and C. Durucan, “Complete chemical and structural characterization of selenium-incorporated hydroxyapatite,” JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, vol. 33, no. 1, pp. 0–0, 2022, Accessed: 00, 2022. [Online]. Available: https://hdl.handle.net/11511/95187.