Date

2021-12-21

Author

İşler Binay, Melda

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The development of more efficient and eco-friendly antimicrobial agents with a broader spectrum plays a significant role in culminating prolonged treatment and higher global health. However, the worldwide rise multidrug-resistant bacteria has made traditional approaches to controlling infectious diseases problematic. As a result, developing new classes of antimicrobial medicines capable of treating resistant bacteria is critical. It is stated that using a host as a matrix in applying some antimicrobial agent increases the antimicrobial activity and offers tailorable release. This thesis aims to contribute to the literature with the newly developed antimicrobial host-guest systems. In the first part of this study, the process of converting the impurity containing locally available natural kaolin into an antimicrobial filler and adding it to the electrostatic powder paint was investigated. In this process, several combinations of binary metal exchanged zeolite A crystals were studied, and an antimicrobial powder paint was developed in partnership industry with IBA KIMYA. The Ag+ and Zn2+ exchanged zeolite A crystals were added into electrostatic powder paint for this aim, verifying esthetic regulations fulfilling the need of the powder paint industry. The usage of silver has been a controversial issue due to the increased silver contamination in the environment in the last decades. Thus, the second and third parts of the thesis were established based on the need for new environmentally-friendly antimicrobial agents. In the second part of the thesis, the novel antimicrobial host-guest system was developed using thymol, the main component of essential oil thyme, and Titanosilicate ETS-10 crystals. For the encapsulation of thymol, post-treatment of ETS-10 was applied to obtain a hierarchical pore structure in ETS-10. This approach enabled one to enhance the amount loaded and extend the release profile for the purpose of increased antimicrobial efficiency obtained from thymol encapsulation. In the last part of this study, the first two approaches were combined by bringing Zn2+ and thymol in the post-treated zeolite X. This superior system offered more effective antimicrobial activity than its counterparts; i.e., thymol/Zn-commercial zeolite X or thymol-post-treated zeolite X systems. This thesis proposes antimicrobial post-treated carriers to support large thymol payloads that take advantage of a complex form, offering controlled and tailorable release. The high accessibility of the surface area coming from the post-treated process was key to obtain these results. We believe that these systems are suitable for large-scale applications and show potential compared to those seeking antimicrobial solutions.

Subject Keywords

Post-synthesis Treatments for Zeolites, Antimicrobial Activity, Essential Oils, Metal Cations, Sustained Release

URI

https://hdl.handle.net/11511/95248

Collections

Graduate School of Natural and Applied Sciences, Thesis