Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model

Download

1-s2.0-S2589004221013407-main.pdf

Date

2021-12-01

Author

Degirmenci, Bahar
Dincer, Cansu
Demirel, Habibe Cansu
Berkova, Linda
Moor, Andreas E.
Kahraman, Abdullah
Hausmann, George
Aguet, Michel
Tunçbağ, Nurcan
Valenta, Tomas
Basler, Konrad

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

85
views

30
downloads

Colon cancer is initiated by stem cells that escape the strict control. This process is often driven through aberrant activation of Wnt signaling by mutations in components acting downstream of the receptor complex that unfetter tumor cells from the need for Wnts. Here we describe a class of colon cancer that does not depend on mutated core components of the Wnt pathway. Genetically blocking Wnt secretion from epithelial cells of such tumors results in apoptosis, reduced expression of colon cancer markers, followed by enhanced tumor differentiation. In contrast to the normal colonic epithelium, such tumor cells autosecrete Wnts to maintain their uncontrolled proliferative behavior. In humans, we determined certain cases of colon cancers in which the Wnt pathway is hyperactive, but not through mutations in its core components. Our findings illuminate the path in therapy to find further subtypes of Wnt-dependent colon cancer that might be to Wnt secretion inhibitors.

URI

https://hdl.handle.net/11511/96023

Journal

ISCIENCE

DOI

https://doi.org/10.1016/j.isci.2021.103369

Collections

Graduate School of Informatics, Article

Suggestions

OpenMETU
Core

CpG oligodeoxynucleotide- loaded PAMAM dendrimer-coated magnetic nanoparticles promote apoptosis in breast cancer cells Pourianazar, Negar Taghavi; Gündüz, Ufuk (2016-03-01) One major application of nanotechnology in cancer treatment involves designing nanoparticles to deliver drugs, oligonucleotides, and genes to cancer cells. Nanoparticles should be engineered so that they could target and destroy tumor cells with minimal damage to healthy tissues. This research aims to develop an appropriate and efficient nanocarrier, having the ability of interacting with and delivering CpG-oligodeoxynucleotides (CpG-ODNs) to tumor cells. CpG-ODNs activate Toll-like receptor 9 (TLR9), which...
Poly (Dl-Lactic-Co-Glycolic Acid) microparticles and synthetic peptide drug conjugate for anti-cancer drug delivery Şen, Gülseren Petek; Gündüz, Ufuk; Department of Biotechnology (2009) Cancer is a group of diseases in which normal cells are converted to cells capable of autonomous growth and invasion. In the chemotherapeutic control of cancer, drugs are usually given systemically so they reach toxic levels in healthy cells as well as cancer cells. This causes serious side effects. Another important problem with chemotherapy is resistance developed to cytotoxic drugs (multi drug resistance). Doxorubicin (Dox) occupies a central position in the treatment of breast cancer. However doxorubici...
ANALYSIS OF TRANSCRIPTOME DATA FOR THE EVALUATION OF METABOLIC DEREGULATION IN CANCER Sheraj, Ilir; Banerjee, Sreeparna; Department of Biology (2021-6-28) The great potential of cancer metabolism in tumor development as well as treatment has been appreciated in recent years. In this study, an extensive list of enzymes relevant to central cellular metabolism and metabolite transporters were manually curated. A pan cancer differential expression of these genes between tumor and their normal counterpart was analyzed in an attempt to better understand tumor bioenergetics, catabolism and anabolism in general. Major deregulation of these genes, particularly the enz...
Targeted delivery of CPG-oligodeoxynucleotide to breast cancer cells by poly-amidoamine dendrimer-modified magnetic nanoparticles Taghavi Pourianazar, Negar; Gündüz, Ufuk; Gündüz, Güngör; Department of Biotechnology (2016) One major application of nanotechnology in cancer treatment involves designing nanoparticles to deliver drugs, oligonucleotides, and genes to cancer cells. Nanoparticles should be engineered so that they could target and destroy tumor cells with minimal damage to healthy tissues. This research aims to develop an appropriate and efficient nanocarrier, having the ability of interacting with and delivering CpG-oligodeoxynucleotides (CpG-ODNs) to tumor cells. CpG-ODNs activate Toll-like receptor 9 (TLR9), which...
Apoptotic Effects of Resveratrol, a Grape Polyphenol, on Imatinib-Sensitive and Resistant K562 Chronic Myeloid Leukemia Cells Can, Geylani; Cakir, Zeynep; Kartal, Melts; Gündüz, Ufuk; BARAN, YUSUF (2012-07-01) Aim: To examine the antiproliferative and apoptotic effects of resveratrol on imatinib-sensitive and imatinib-resistant K562 chronic myeloid leukemia cells. Materials and Methods: Antiproliferative effects of resveratrol were determined by the 3-Bis[2-methoxy-4-nitro-5-sulphophenyl]-2H-tetrazolium-5-carboxanilide inner salt (XTT) cell proliferation assay. Apoptotic effects of resveratrol on sensitive K562 and resistant K562/IMA-3 cells were determined through changes in caspase-3 activity, loss of mitochond...

Citation Formats

B. Degirmenci et al., “Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model,” ISCIENCE, vol. 24, no. 12, pp. 0–0, 2021, Accessed: 00, 2022. [Online]. Available: https://hdl.handle.net/11511/96023.