Transparency too little, too late? Why and how Health Canada should make clinical data and regulatory decision-making open to scrutiny in the face of COVID-19

Edmonds, Sterling
Macgregor, Andrea
Doll, Agnieszka
Eren Vural, İpek
Graham, Janice
Fierlbeck, Katherine
Lexchin, Joel
Doshi, Peter
Herder, Matthew


Scramjet Combustor Flow Analysis Using Coupled Navier-Stokes and Finite Rate Chemical Equations
Rouzbar, Ramin; Eyi, Sinan (2016-07-13)
An element-index is a crucial mechanism for supporting content-only (CO) queries over XML collections. A full element-index that indexes each element along with the content of its descendants involves a high redundancy and reduces query processing efficiency. A direct index, on the other hand, only indexes the content that is directly under each element and disregards the descendants. This results in a smaller index, but possibly in return to some reduction in system effectiveness. In this paper, we propose...
Prospective evaluation of Vitamin K2, Raloxifene and their co-administration in osteoporotic rats
Tasci, A. G.; BİLGİLİ, HASAN; Altunay, H.; Gecit, M. R.; Keskin, Dilek (Elsevier BV, 2011-07-17)
In this study, therapeutic effects of Vitamin K2, Raloxifene and their co-administration on bone, uterus, blood and weight profiles were investigated with an ovariectomized rat model. Forty Wistar rats were divided into five groups (n = 8): Raloxifene (R), Vitamin K2 (K), Raloxifene + Vitamin K2 (R + K), ovariectomized controls (OVX) and Sham-operated controls (Sham). Treatment began 3 months after ovariectomy. Vitamin K2 and Raloxifene were administered 30 and 1.5 mg/kg/day separately and in combination fi...
Novel synthetic methodologies for heterocycles as building blocks in drug synthesis
Subaşı, Nuriye Tuna; Demir, Ayhan Sıtkı; Department of Chemistry (2011)
Nitrogen containing heterocycles have always constituted a subject of great interest due to their wide presence in biologically important compounds so the development of efficient methods for the preparation of pyrrole derivatives and formation of new pyrrole-based heterocyclic compounds are an attractive goal in heterocyclic chemistry. In this study, starting from dimethoxytetrahydrofurane and amino acid esters, unsubstituted pyrrole derivatives, and treatment of amino acid esters with convenient chloroeno...
Cyber-physical-based PAT (CPbPAT) framework for Pharma 4.0
VATANKHAH BARENJI, REZA; Akdag, Yagmur; Yet, Barbaros; ÖNER, LEVENT (Elsevier BV, 2019-08-01)
Industry 4.0 aims to integrate manufacturing operations into a seamless digital whole by incorporating flexibility, agility, re-configurability, and sustainability. The result of this integration is a "smart factory" that is more lean, agile, and flexible in operations. There are valid reasons, and perhaps requirements, for pharmaceutical industries to embrace smart factory and to "borrow" the concept of Industry 4.0 to give rise to "Pharma 4.0" (i.e., the pharmaceutical version of Industry 4.0). This paper...
Micro processing by intense fast electron beam
Goktas, H; Kirkici, H; Oke, G; Udrea, M (2001-06-22)
Generation of intense electron beams by superposing two discharges, namely a low pressure do glow discharge and a high current pulsed discharge at pressures and voltages very similar to that of the pseudo-spark gap devices, has been reported previously [1, 2]. The small diameter, high peak current and short pulse length are the characteristics of the electron beam generated using this technique. In this technique, no high vacuum facilities are necessary, and many applications such as micro processing, X-ray...
Citation Formats
S. Edmonds et al., “Transparency too little, too late? Why and how Health Canada should make clinical data and regulatory decision-making open to scrutiny in the face of COVID-19,” Journal of Law and the Biosciences, vol. 7, no. 1, pp. 0–0, 2020, Accessed: 00, 2022. [Online]. Available: