Now showing items 1-4 of 4
Determination of Autophagy in the Caco-2 Spontaneously Differentiating Model of Intestinal Epithelial Cells
(Springer New York, 2017)
The Caco-2 colorectal cancer cell line is widely used as a model for intestinal differentiation and barrier function. These cells, upon reaching confluency, spontaneously differentiate into enterocyte-like cells, synthesize ...
Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2-MSH6 complex
(Oxford University Press (OUP), 2005-2-23)
Cadmium (Cd2(+)) is a known carcinogen that inactivates the DNA mismatch repair (MMR) pathway. In this study, we have tested the effect of Cd2+ exposure on the enzymatic activity of the mismatch binding complex MSH2-MSH6. ...
CHNQ, a novel 2-Chloro-1,4-naphthoquinone derivative of quercetin, induces oxidative stress and autophagy both in vitro and in vivo
(Elsevier BV, 2016-4)
Quercetin (Qc) shows strong antitumor effects but has limited clinical application due to poor water solubility and bioavailability. In a screening of novel semi-synthetic derivatives of Qc, 3,7-dihydroxy-2-[4-(2-chloro- ...
Enhanced expression of HNF4 alpha during intestinal epithelial differentiation is involved in the activation of ER stress
(WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2019-12)
Intestinal epithelial cells are derived from stem cells at the crypts that undergo differentiation into transit-amplifying cells, which in turn form terminally differentiated enterocytes as these cells reach the villus. ...