Doksorubisin üklü Dekstran kaplı manyetik nanoparçacıkların MCF-7 meme kanseri hücre hattında sitokin genlerinin ifade düzeyleri üzerindeki etkileri

Date

2017-02-23

Author

Yalçın Azarkan, Serap
Mutlu, Pelin
Gündüz, Ufuk

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https://hdl.handle.net/11511/83832

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Metastatic behaviour of doxorubicin resistant MCF-7 breast cancer cells after Vimentin silencing Tezcan, Okan; Gündüz, Ufuk; Department of Biology (2013) Chemotherapy is one of the common treatments in cancer therapy. The effectiveness of chemotherapy is limited by several factors one of which is the emergence of multidrug resistance (MDR). MDR is caused by the activity of diverse ATP binding cassette (ABC) transporters that pump drugs out of the cells. There are several drugs which have been used in treatment of cancer. One of them is doxorubicin that intercalates and inhibits DNA replication. However, doxorubicin has been found to cause development of MDR ...
The Effects of doxorubicin containing poly (sebacic anhydride) nanocapsules on glutathione s-transferase activity Çokça, Ceren; Hasırcı, Nesrin; İşgör, S. Belgin; Department of Biomedical Engineering (2015) Nanocapsules are used as drug delivery system commonly. Poly (sebacic anhydride) is a good candidate for the nanocapsule preparation since they are ideal for controlled release application with respect to biocompatibility, low cost, and the approval by US Food and Drug Administration (FDA). The overactivity of glutathione S-transferase is generally related with the resistance of chemotherapy and this problem can be overcome through drug delivery systems. In this study, poly (sebacic anhydride) - poly (ethyl...
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Citation Formats

S. Yalçın Azarkan, P. Mutlu, and U. Gündüz, “Doksorubisin üklü Dekstran kaplı manyetik nanoparçacıkların MCF-7 meme kanseri hücre hattında sitokin genlerinin ifade düzeyleri üzerindeki etkileri,” 2017, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/83832.