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Bioprinted scaffolds assembled as synthetic skin grafts by natural hydrogels containing fibroblasts and bioactive agents
Date
2023-01-01
Author
Bostancı, Nazlı Seray
Büyüksungur, Senem
Hasırcı, Nesrin
Tezcaner, Ayşen
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Hydrogel skin grafts provide a moist environment and act as a regenerative template to the newly formed tissue. In this study, we developed 3D-bio-printed hydrogels using methacrylated pectin and methacrylated gelatin together with an antibacterial agent (curcumin), a bioactive agent (Vitamin-C) and fibroblast cells. Curcumin release was almost 10 times higher at pH 7.4 than pH 5.0, and it demonstrated antimicrobial affinity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. The developed 3D-bio-printed hydrogels containing cells and bioactive agents demonstrated high cell viability, cell proliferation, and collagen production, and are promising skin graft candidates for the treatment of full-thickness problematic wounds.
Subject Keywords
3D bioprinting
,
3D printing
,
curcumin
,
skin graft
,
Vitamin-C
URI
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85164467986&origin=inward
https://hdl.handle.net/11511/104705
Journal
International Journal of Polymeric Materials and Polymeric Biomaterials
DOI
https://doi.org/10.1080/00914037.2023.2230339
Collections
Graduate School of Natural and Applied Sciences, Article
Citation Formats
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BibTeX
N. S. Bostancı, S. Büyüksungur, N. Hasırcı, and A. Tezcaner, “Bioprinted scaffolds assembled as synthetic skin grafts by natural hydrogels containing fibroblasts and bioactive agents,”
International Journal of Polymeric Materials and Polymeric Biomaterials
, pp. 0–0, 2023, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85164467986&origin=inward.