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Resistance Welding of PAEK / Carbon Fiber Thermoplastic Composite Laminates Martı, İsmail Baha; Kaynak, Cevdet; Department of Metallurgical and Materials Engineering (2023-1-20) The main purpose of this thesis is, as the first time in the literature, to investigate usability of resistance welding joining method for poly(aryletherketone) (PAEK) thermoplastic matrix carbon fiber (CF) reinforced composite laminates (PAEK/CF). For this purpose, effects of six different Interlayer Forms having different stainless steel meshes as Heating Elements and different woven glass fiber forms as Insulating Layers were studied. After determining welding parameters for each specimen group, performa...
Metabolomics analysis of iPSCs derived organoids Sarı , Vedat; Koçak , Gamze; Reçber, Tuba; Karakülah , Gökhan; Utine , Canan Aslı; Nemutlu , Emirhan; Güven, Sinan (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) Regenerative medicine is focused on functional restoration of a particular tissue and organs. Stem cell based miniaturized heterogenous cellular clusters named organoids, exhibit features of organ functionality, self-organization, multicellularity, and utility. Induced pluripotent stem cells (iPSCs), have great potential to develop organoids of specific tissues and utilized in regenerative medicine. Organoid technologies have revolutionized the approach to human development and diseases, providing outstandi...
DiPPI: Drugs in Protein-Protein Interaction Interfaces Cankara, Fatma; Şenyüz , Simge; Keskin , Özlem; Gürsoy , Attila (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) Protein-protein interactions (PPIs) modulation has been associated with various diseases. Proteins interact through their interfaces and interface characterization is important to understand the underlying mechanisms of the interaction. There has been an increasing interest in PPIs as drug targets, as analysis of binding regions and critical contacts may reveal more information about these mechanisms. Therefore, investigating the properties of the interactions is critical for the identification of drug targ...
Amino Acid Occurrence Rates in the SARS-CoV-2 Proteome Adıgüzel , Yekbun (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) This study aims to investigate SARS-CoV-2 amino acid (aa) occurrence rates (i.e., frequencies) to compare those with that of humans, assuming/expecting higher number of host-pathogen common sequences in the respective proteomes with closer aa frequencies. It can be related to adaptation, and can put susceptible individuals into the molecular mimicry-based autoimmunity risk upon infection. With the given aim, frequencies of aa in the viral proteome were obtained from 12 proteins in the reference genome of SA...
Characterizing the potential interplay between nucleotide excision repair and R-loops Kaya, Sezgi; Adebali, Ogün (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) R-loops have been a focus of interest in genomics due to their non-canonical structures and unclear roles on genomes of many organisms. While R-loops contribute to gene expression and efficient transcriptional termination, they cause genome instability under certain conditions. They are formed when an RNA anneals with its complementary DNA strand. A DNA:RNA hybrid is formed and the other strand of DNA is left single-stranded (ssDNA). To date, there was no clear knowledge on R-loops’ tendency for UV damage f...

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