In vitro digestion of polysaccharide including whey protein isolate hydrogels

Hydrogels are great systems for bioactive agent encapsulation and delivery. In this study, polysaccharide blended whey protein isolate (WPI) based hydrogels were loaded with black carrot (Daucus carota) concentrate (BC) and in vitro gastrointestinal release measurements were performed. Prior to 6 h digestion in simulated intestinal fluid (SIF), all hydrogels were exposed to simulated gastric fluid (SGF) for 2 h. Pectin (PC), gum tragacanth (GT) and xanthan gum (XG) were the polysaccharides used with WPI to manipulate the release behavior. Physico-chemical changes of the hydrogels throughout the digestion were evaluated by Fourier transform infrared (FTIR) spectroscopy and nuclear magnetic resonance (NMR) relaxometry measurements. Each polysaccharide induced different physico-chemical interactions within the hydrogels due to their distinct structural characteristics. Polysaccharide blending to hydrogels also retarded the release rates in all samples in SIF (p < 0.05). Moreover, microstructural differences between hydrogels were evaluated by scanning electron microscope (SEM) images.


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Özel, Barış; Aydin, Ozlem; Öztop, Halil Mecit (2017-10-01)
Design and characterization of composite whey protein isolate (WPI) hydrogels are gaining interest due to their utilization as controlled delivery matrices for bioactive agents. In this study, black carrot extract (BC) loaded composite WPI hydrogels, containing xanthan (XN), pectin (PC) and gum tragacanth (GT) were prepared by conventional water bath (CV) and infrared (IR) assisted microwave heating (MW). Release and swelling experiments were conducted at pH 7.0 phosphate buffer solution for 24 h. Highest s...
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Citation Formats
B. Özel and H. M. Öztop, “In vitro digestion of polysaccharide including whey protein isolate hydrogels,” CARBOHYDRATE POLYMERS, pp. 0–0, 2020, Accessed: 00, 2020. [Online]. Available: