pH and Temperature Triggered Release of Doxorubicin from Hydrogen bonded Multilayer Thin Films of Poly 2 isoprpoyl 2 oxazoline

Haktanıyan, Meltem
Atilla, Süleyman
Erel Göktepe, İrem
Çağlı, Eda


pH- and temperature-induced release of doxorubicin from multilayers of poly(2-isopropyl-2-oxazoline) and tannic acid
Haktanıyan, Meltem; Atilla, Suleyman; Çağlı, Eda; Erel Göktepe, İrem (Wiley, 2017-12-01)
We present a simple strategy to prepare doxorubicin (DOX) containing hydrogen-bonded films of poly(2-isopropyl-2-oxazoline) (PIPOX) and tannic acid (TA) which release DOX in acidic conditions while releasing a minimal amount of DOX at physiological pH. Water soluble complexes of TA and DOX (TA-DOX) were prepared prior to film construction. PIPOX and TA-DOX were deposited at the surface at pH6.5 using the layer-by-layer (LbL) technique. We found that multilayers released a minimal amount of DOX at physiologi...
pH influences metabolite profiling of beta-lactamse producing B-licheniformis
Ileri, N; Çalık, Pınar; Sengul, A (2005-08-01)
PH influences intracellular reaction network of beta-lactamase producing Bacillus licheniformis
Çalık, Pınar (Elsevier BV, 2007-09-01)
Effects of pH on metabolic flux distributions in P-lactamase producing Bacillus licheniformis were investigated using metabolic flux analysis, at pH(C) = 6.5, 7.0 and 7.5 controlled-pH conditions. The bioprocess was divided into three periods: Period I (0 < t < 6 h) is the growth phase where beta-lactamase synthesis starts; Period II (6 < t < 8 h) is the transition phase; Period III (8 < t < 12 h) is the stationary phase for the cell-growth where beta-lactamase synthesis increases. The central pathways were...
pH-responsive layer-by-layer films of zwitterionic block copolymer micelles
Yusan, Pelin; Tuncel, Irem; Butun, Vural; Demirel, A. Levent; Erel Göktepe, İrem (2014-01-01)
We report a strategy to incorporate micelles of poly[3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate]-block-poly[2-(diisopropylamino) ethyl methacrylate] (beta PDMA-b-PDPA) into electrostatic layer-by-layer (LbL) films. We obtained micelles with pH-responsive PDPA-cores and zwitterionic bPDMA-coronae at pH 8.5 through pH-induced self-assembly of bPDMA-b-PDPA in aqueous solution. To incorporate bPDMA-b-PDPA micelles into LbL films, we first obtained a net electrical charge on bPDMA-coronae. Nega...
pH-dependent conformational changes and thermal stability of outer membrane protein G mutants by Fourier transform infrared spectroscopy
Yılmaz, İsmail Ömer; KORKMAZ ÖZKAN, FİLİZ (2016-09-01)
Citation Formats
M. Haktanıyan, S. Atilla, İ. Erel Göktepe, and E. Çağlı, “pH and Temperature Triggered Release of Doxorubicin from Hydrogen bonded Multilayer Thin Films of Poly 2 isoprpoyl 2 oxazoline,” 2016, Accessed: 00, 2021. [Online]. Available: