pH and Temperature Triggered Release of Doxorubicin from Hydrogen bonded Multilayer Thin Films of Poly 2 isoprpoyl 2 oxazoline

2016-09-16
Haktanıyan, Meltem
Atilla, Süleyman
Erel Göktepe, İrem
Çağlı, Eda

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We present a simple strategy to prepare doxorubicin (DOX) containing hydrogen-bonded films of poly(2-isopropyl-2-oxazoline) (PIPOX) and tannic acid (TA) which release DOX in acidic conditions while releasing a minimal amount of DOX at physiological pH. Water soluble complexes of TA and DOX (TA-DOX) were prepared prior to film construction. PIPOX and TA-DOX were deposited at the surface at pH6.5 using the layer-by-layer (LbL) technique. We found that multilayers released a minimal amount of DOX at physiologi...
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Citation Formats
M. Haktanıyan, S. Atilla, İ. Erel Göktepe, and E. Çağlı, “pH and Temperature Triggered Release of Doxorubicin from Hydrogen bonded Multilayer Thin Films of Poly 2 isoprpoyl 2 oxazoline,” 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/80450.