In Silico Modeling of Electrical and Mechanical Disorders in Cardiac Tissue

Berberoğlu, Ezgi
Göktepe, Serdar


In silico modeling and in vitro validation of undefined off-target of drugs in hepatocellular carcinoma
Sinoplu, Esra; Tunçbağ, Nurcan; Kahraman, Deniz C.; Atalay, Rengül (2019-07-01)
Hepatocellular carcinoma (HCC) is the 5th most common and 2nd deadliest cancer worldwide. The molecular mechanism in HCC involves activated cell survival pathways, but there is a lack of the significant oncogenic drivers for targeted therapies. Thus, novel drugs and targets that can be exploited, are required. The pathways reported to be involved in hepatocarcinogenesis were retrieved from KEGG database (HCC, MAPK, calcium, p53, PI3K-Akt, Wnt, TGF-B, NAFLD and apoptosis) and a directed network with 801 node...
In-situ observation and numerical study of dynamic delamination in tapered composite laminates
Dashatan, Saeid Hosseinpour; Parnas, Kemal Levend; Çöker, Demirkan; Bozkurt, Mirac Onur; Ozen, Emine Burcin (2023-05-15)
In this study, dynamic delamination behavior in asymmetric GFRP tapered laminates under quasi-static tensile loading is investigated experimentally and numerically. Abaqus/Explicit cohesive interface modeling is utilized to simulate delamination initiation and dynamic propagation. Time-frame based delamination mechanisms predicted in simulations are compared to in-situ high-speed camera images for four geometrically asymmetric specimens containing grouped and ungrouped drop-off types. It is observed that th...
In-flight Ice formation simulation on finite wings and air intakes
Özgen, Serkan (2012-04-01)
In the present article, in-flight ice formation on finite wings and air intakes of low-speed aircraft are numerically studied. The approach to the problem involves calculation of the velocity field using a three-dimensional panel method. Using the calculated velocity field, the droplet trajectories and droplet impact locations are computed yielding the droplet collection efficiency distribution. In the next step, convective heat transfer coefficient distributions around the geometries are calculated using a...
In-flight icing simulation on engine nacelles
Uğur, Nermin; Özgen, Serkan; Department of Aerospace Engineering (2017)
In-flight ice accumulation on airframes may lead to great risks for flight safety due to aerodynamic performance degradation, loss of control, engine rollback and increase in weight. Certification concerns become an important topic when flight safety is considered. To prove that an aircraft can fly safely in certain icing conditions, authorities like FAA and EASA have defined meteorological conditions. Flight tests, laboratory tests and numerical simulations are the methods utilized to show compliance with ...
In-situ observation of nano-oxide and defect evolution in 14YWT alloys
Aydoğan Güngör, Eda; Li, M.; Maloy, S.A. (Elsevier BV, 2020-12-01)
© 2020 Elsevier Inc.Nanostructured ferritic alloys (NFAs) are considered as candidates for structural components in advanced nuclear reactors due to their excellent radiation resistance as a result of a high density of nano-oxides (NOs) in the microstructure. Therefore, gaining an understanding on the stability of NOs under irradiation is crucial. In this study, we have investigated the evolution of defects and NOs in 14YWT NFAs under in-situ Kr ion irradiation at room temperature (RT) and 450 °C up to 10 d...
Citation Formats
E. Berberoğlu and S. Göktepe, “In Silico Modeling of Electrical and Mechanical Disorders in Cardiac Tissue,” 2015, Accessed: 00, 2021. [Online]. Available: