Principal microbial groups: compositional alternative to phylogenetic grouping of microbiome data

Date

2022-08-01

Author

Boyraz, Asli
Pawlowsky-Glahn, Vera
Jose Egozcue, Juan
Acar, Aybar Can

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Statistical and machine learning techniques based on relative abundances have been used to predict health conditions and to identify microbial biomarkers. However, high dimensionality, sparsity and the compositional nature of microbiome data represent statistical challenges. On the other hand, the taxon grouping allows summarizing microbiome abundance with a coarser resolution in a lower dimension, but it presents new challenges when correlating taxa with a disease. In this work, we present a novel approach that groups Operational Taxonomical Units (OTUs) based only on relative abundances as an alternative to taxon grouping. The proposed procedure acknowledges the compositional data making use of principal balances. The identified groups are called Principal Microbial Groups (PMGs). The procedure reduces the need for user-defined aggregation of (OTUs) and offers the possibility of working with coarse group of OTUs, which are not present in a phylogenetic tree. PMGs can be used for two different goals: (1) as a dimensionality reduction method for compositional data, (2) as an aggregation procedure that provides an alternative to taxon grouping for construction of microbial balances afterward used for disease prediction. We illustrate the procedure with a cirrhosis study data. PMGs provide a coherent data analysis for the search of biomarkers in human microbiota. The source code and demo data for PMGs are available at: https://github.com/asliboyraz/PMGs.

Subject Keywords

microbiome, compositional data, balance, microbial biomarkers, HUMAN GUT MICROBIOME, METAGENOMICS, ASSOCIATION

URI

https://hdl.handle.net/11511/100168

Journal

BRIEFINGS IN BIOINFORMATICS

DOI

https://doi.org/10.1093/bib/bbac328

Collections

Graduate School of Informatics, Article

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Citation Formats

A. Boyraz, V. Pawlowsky-Glahn, J. Jose Egozcue, and A. C. Acar, “Principal microbial groups: compositional alternative to phylogenetic grouping of microbiome data,” BRIEFINGS IN BIOINFORMATICS, pp. 0–0, 2022, Accessed: 00, 2022. [Online]. Available: https://hdl.handle.net/11511/100168.