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Assessing generalisability of deep learning-based polyp detection and segmentation methods through a computer vision challenge
Ali, Sharib; et. al. (2024-12-01)
Polyps are well-known cancer precursors identified by colonoscopy. However, variability in their size, appearance, and location makes the detection of polyps challenging. Moreover, colonoscopy surveillance and removal of p...
FPGA-friendly compact and efficient AES-like 8 × 8 S-box
Malal, Ahmet; Tezcan, Cihangir (2024-03-01)
One of the main layers in the Advanced Encryption Standard (AES) is the substitution layer, where an 8 × 8 S-Box is used 16 times. The substitution layer provides confusion and makes the algorithm resistant to cryptanalysi...
An integrative framework for clinical diagnosis and knowledge discovery from exome sequencing data
Shojaei, Mona; Mohammadvand, Navid; DOĞAN, TUNCA; Alkan, Can; Çetin Atalay, Rengül; Acar, Aybar Can (2024-02-01)
Non-silent single nucleotide genetic variants, like nonsense changes and insertion-deletion variants, that affect protein function and length substantially are prevalent and are frequently misclassified. The low sensitivit...
Abnormally low sensorimotor α band nonlinearity serves as an effective EEG biomarker of Parkinson’s disease
Özkurt, Tolga Esat (2024-02-01)
Biomarkers obtained from the neurophysiological signals of patients with Parkinson’s disease (PD) have objective value in assessing their motor condition for effective diagnosis, monitoring, and clinical intervention. Prom...
BioNet-XR: Biological Network Visualization Framework for Virtual Reality and Mixed Reality Environments
Şenderin, Büşra; Tunçbağ, Nurcan; Sürer, Elif (2024-02-01)
Protein-protein interaction networks (PPIN) enable the study of cellular processes in organisms. Visualizing PPINs in extended reality (XR), including virtual reality (VR) and mixed reality (MR), is crucial for exploring s...
Spatiotemporal signal space separation for regions of interest: Application for extracting neuromagnetic responses evoked by deep brain stimulation
Oswal, Ashwini; Abdi-Sargezeh, Bahman; Sharma, Abhinav; Özkurt, Tolga Esat; Taulu, Samu; Sarangmat, Nagaraja; Green, Alexander L.; Litvak, Vladimir (2024-02-01)
Magnetoencephalography (MEG) recordings are often contaminated by interference that can exceed the amplitude of physiological brain activity by several orders of magnitude. Furthermore, the activity of interference sources...
A Modular Serious Game Development Framework for Virtual Laboratory Courses
Yucel, Furkan; Sultan Unal, Hasret; Sürer, Elif; Huvaj Sarıhan, Nejan (2024-01-01)
Laboratory experience is an integral part of the undergraduate curriculum in most engineering courses. When physical learning is not feasible, and when the demand cannot be met through actual hands-on laboratory sessions, ...
Quasi-Newton FDE in One-Bit Pseudo-Randomly Quantized Massive MIMO-OFDM Systems
Yılmaz, Gökçen; Yılmaz, Ali Özgür (2024-01-01)
This letter offers a new frequency-domain equalization (FDE) scheme that can work with a pseudo-random quantization (PRQ) scheme utilizing non-zero threshold quantization in one-bit uplink multi-user massive multiple-input...
Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
Hawash, Mohammed; Jaradat, Nidal; Abualhasan, Murad; ŞÜKÜROĞLU, MURAT KADİR; Qaoud, Mohammed T.; Kahraman, Deniz Cansen; Daraghmeh, Heba; Maslamani, Leen; Sawafta, Mais; Ratrout, Ala; Issa, Linda (2023-12-01)
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been the most commonly used class of medications worldwide for the last three decades. Objectives: This study aimed to design and synthesize a novel series of ...
Pan-cancer clinical impact of latent drivers from double mutations
Yavuz, Bengi Ruken; Tsai, Chung-Jung; Nussinov, Ruth; Tuncbag, Nurcan (2023-12-01)
Here, we discover potential ‘latent driver’ mutations in cancer genomes. Latent drivers have low frequencies and minor observable translational potential. As such, to date they have escaped identification. Their discovery ...
An automated framework for evaluation of deep learning models for splice site predictions
Zabardast, Amin; Tamer, Elif Güney; Aydın Son, Yeşim; Yılmaz, Arif (2023-12-01)
A novel framework for the automated evaluation of various deep learning-based splice site detectors is presented. The framework eliminates time-consuming development and experimenting activities for different codebases, ar...
Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome
Yavuz, Bengi Ruken; Arici, M. Kaan; Demirel, Habibe Cansu; Tsai, Chung-Jung; Jang, Hyunbum; Nussinov, Ruth; Tunçbağ, Nurcan (2023-12-01)
Epidemiological studies suggest that individuals with neurodevelopmental disorders (NDDs) are more prone to develop certain types of cancer. Notably, however, the case statistics can be impacted by late discovery of cancer...
sphstat: A Python package for inferential statistics on vectorial data on the unit sphere
Hacıhabiboğlu, Hüseyin (2023-12-01)
Data that resides on the surface of a 2-sphere is common in various scientific fields, including physics, earth sciences, astronomy, and psychoacoustics. While some tools and packages exist for performing inferential stati...
Health-Related Work Loss: Wellness Profiles of Information Technology Employees
Kuru, Hakan; Sakmar, Elçin; Aydın Son, Yeşim; İnce, Mustafa Levent (2023-12-01)
Understanding health-related work loss and creating a comprehensive approach requires the identification of lifestyle behavior patterns. An essential part of this process is the examination of different profiles within the...
Categorization of Technical Debt in Software as a Service Applications
Özcan Top, Özden; KURANEL, YASEMİN; Koçyiğit, Altan (2023-12-01)
Technical debt (TD) refers to the outcomes of making poor decisions or choosing simpler solutions generally for the sake of faster code delivery in software development projects. Eventually, TD is repaid and usually the lo...
Why do People Avoid Visiting Specialist Doctors? Answers from a Developing Country: Turkey Case
Sülkü, Seher Nur; TOKATLIOĞLU, YAĞMUR (2023-12-01)
Avoid seeking medical care deemed necessary has severe negative effects on health. Indeed, delayed presentation of patients puts a significant burden on healthcare costs. There is limited literature examining the avoidance...
The impact of the covid-19 outbreak on unmet health care needs in istanbul
TOKATLIOĞLU, YAĞMUR; Sülkü, Seher Nur (2023-12-01)
Background & aim: COVID-19 pandemic caused significant barriers to maintain health services. Our study determines the frequency and significant determinants of unmet health needs in Istanbul both in 2019, a prepandemic yea...
Measuring efficiency of public hospitals under the impact of Covid-19: the case of Turkiye
Sülkü, Seher Nur; Mortas, Alper; Kucuk, Aziz (2023-12-01)
The Covid-19 pandemic has had serious medical, administrative and financial effects on the health system and hospitals around the world. In Turkiye, compared to 2019 realizations, in 2020 and 2021 respectively there were 3...
Receiving or not deemed necessary healthcare services
Sülkü, Seher Nur; TOKATLIOĞLU, YAĞMUR; COŞAR, KÜBRA (2023-12-01)
BackgroundAvoiding deemed necessary healthcare needs may worsen prognosis and treatment options, and damage people's ability to perform their roles in society. Our study investigates why people avoid healthcare services in...
Empowering Universities as Strong Communities and Change Catalyzers
Alemdar, Serdar; Sürer, Elif (2023-11-01)
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