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A process assessment model for big data analytics Gökalp, Mert Onuralp; Gökalp, Ebru; Kayabay, Kerem; Gökalp, Selin; Koçyiğit, Altan; Eren, Pekin Erhan (2022-03-01) © 2021Today, business success is essentially powered by data-centric software. Big data analytics (BDA) grasp the potential of generating valuable insights and empowering businesses to support their strategic decision-maki...
Digital transformation capability maturity model enabling the assessment of industrial manufacturers Gökalp, Ebru; Martinez, Veronica (2021-11-01) © 2021 Elsevier B.V.The utilization of on-premise technologies in the business environment is ushering in a new era known as digital transformation (DX). Although organizations are aware of the potential advantages of DX, ...
Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication Yurtman, Erinç; et. al. (2021-11-01) Sheep were among the first domesticated animals, but their demographic history is little understood. Here we analyzed nuclear polymorphism and mitochondrial data (mtDNA) from ancient central and west Anatolian sheep dating...
Synthesis and biological evaluation of novel isoxazole-piperazine hybrids as potential anti-cancer agents with inhibitory effect on liver cancer stem cells Ibis, Kubra; Sinoplu, Esra; ÇALIŞKAN, BURCU; Kahraman, Deniz Cansen; Cetin-Atalay, Rengul; BANOĞLU, ERDEN (2021-10-01) In our effort for the development of novel anticancer therapeutics, a series of isoxazole-piperazine analogues were prepared, and primarily screened for their antiproliferative potential against hepatocellular carcinoma (H...
Analysis of Software Process Improvement Activities in SMEs: A Systematic Literature Review Durmuş, Suna; Özcan Top, Özden; Özkan Yıldırım, Sevgi (2021-10-01) This Software industry is a very significant cog in today’s economic landscape. The majority of these organizations mainly comprise small and medium enterprises (SMEs). These enterprises aim to benefit from Software Proces...
Performance Assessment of the Network Reconstruction Approaches on Various Interactomes Arici, M. Kaan; Tunçbağ, Nurcan (2021-10-01) Beyond the list of molecules, there is a necessity to collectively consider multiple sets of omic data and to reconstruct the connections between the molecules. Especially, pathway reconstruction is crucial to understandin...
A Basic Nietzschean Model in Lieu of the Causal Maxim Özkurt, Tolga Esat (2021-10-01) Causal knowledge unquestionably provides useful means to describe, explain and predict both natural and daily phenomena. This article addresses whether causality as such may not be ontologically primary and looks for an al...
Computational approaches leveraging integrated connections of multi-omic data toward clinical applications Demirel, Habibe Cansu; Arici, Muslum Kaan; Tunçbağ, Nurcan (2021-10-01) In line with the advances in high-throughput technologies, multiple omic datasets have accumulated to study biological systems and diseases coherently. No single omics data type is capable of fully representing cellular ac...
Mechanism of activation and the rewired network: New drug design concepts Nussinov, Ruth; Zhang, Mingzhen; Maloney, Ryan; Tsai, Chung-Jung; Yavuz, Bengi Ruken; Tunçbağ, Nurcan; Jang, Hyunbum (2021-10-01) Precision oncology benefits from effective early phase drug discovery decisions. Recently, drugging inactive protein conformations has shown impressive successes, raising the cardinal questions of which targets can profit ...
Preschool children's use of perceptual-motor knowledge and hierarchical representational skills for tool making Gönül, Gökhan; Takmaz, Ece; Hohenberger, Annette Edeltraud (2021-10-01) Although other animals can make simple tools, the expanded and complex material culture of humans is unprecedented in the animal kingdom. Tool making is a slow and late-developing ability in humans, and preschool children ...
Quality assessment of web-based information on type 2 diabetes Olcer, Didem; Taşkaya Temizel, Tuğba (2021-10-01) Purpose This paper proposes a framework that automatically assesses content coverage and information quality of health websites for end-users. Design/methodology/approach The study investigates the impact of textual and co...
Exploring factors affecting consumers' adoption of wearable devices to track health data Pancar, Tansu; Özkan Yıldırım, Sevgi (2021-10-01)
A Decision Support System for Optimal Selection of Enterprise Information Security Preventative Actions Özdemir Sönmez, Ferda; Günel Kılıç, Banu (2021-09-01)
The development of the data science capability maturity model: a survey-based research Gökalp, Mert Onuralp; Gokalp, Ebru; Kayabay, Kerem; Koçyiğit, Altan; Eren, Pekin Erhan (2021-09-01) Purpose The purpose of this paper is to investigate social and technical drivers of data science practices and develop a standard model for assisting organizations in their digital transformation by providing data science ...
Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management Akkoyun, Emrah; Gharahi, Hamidreza; Kwon, Sebastian T.; Zambrano, Byron A.; Rao, Akshay; Acar, Aybar Can; Lee, Whal; Baek, Seungik (2021-09-01) © 2021 Elsevier B.V.Objective: The maximum diameter measurement of an abdominal aortic aneurysm (AAA), which depends on orthogonal and axial cross-sections or maximally inscribed spheres within the AAA, plays a significant...
Integrative Predictive Modeling of Metastasis in Melanoma Cancer Based on MicroRNA, mRNA, and DNA Methylation Data Kutlay, Aysegul; Aydın Son, Yeşim (2021-09-01) Introduction: Despite the significant progress in understanding cancer biology, the deduction of metastasis is still a challenge in the clinic. Transcriptional regulation is one of the critical mechanisms underlying cancer...
A Dimension Reduction Approach to Player Rankings in European Football Aydemir, Ayşe Elvan; Taşkaya Temizel, Tuğba; Temizel, Alptekin; Preshlenov, Kliment; Strahinov, Daniel (2021-08-24) Player performance evaluation is a challenging problem with multiple dimensions. Football (soccer) is the largest sports industry in terms of monetary value and it is paramount that teams can assess the performance of play...
BenchMetrics: a systematic benchmarking method for binary classification performance metrics Canbek, Gurol; Taşkaya Temizel, Tuğba; SAĞIROĞLU, ŞEREF (2021-08-01) This paper proposes a systematic benchmarking method called BenchMetrics to analyze and compare the robustness of binary classification performance metrics based on the confusion matrix for a crisp classifier. BenchMetrics...
Human inbreeding has decreased in time through the Holocene Ceballos, Francisco C.; Gürün, Kanat; Altınışık, Nefize Ezgi; Gemici, Hasan Can; Karamurat, Cansu; Koptekin, Dilek; Vural, Kıvılcım Başak; Mapelli, Igor; Sağlıcan, Ekin; Sürer, Elif; Erdal, Yılmaz Selim; Götherström, Anders; Özer, Füsun; Atakuman, Çiğdem; Somel, Mehmet (2021-07-01)
Data-driven manufacturing: An assessment model for data science maturity Gökalp, Mert Onuralp; Gökalp, Ebru; KAYABAY, KEREM; Koçyiğit, Altan; Eren, Pekin Erhan (2021-07-01) © 2021 The Society of Manufacturing EngineersToday, data science presents immense opportunities by turning raw data into manufacturing intelligence in data-driven manufacturing that aims to improve operational efficiency a...

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