Integrated analyses of Emodin in breast cancer cell lines

2023-6
Sakallı Tecim, Elif
Breast cancer has been among the most prominent cancers with high incidence rates and mortality. Currently most of the offered therapeutics for treatment are toxic; hence, less toxic therapeutic intervention is required. Here, we studied the molecular mechanisms of the effect of a phytoestrogen Emodin on estrogen receptor positive MCF- 7 and negative MDA-MB-231 cells by carrying out a comprehensive network assessment. Differentially expressed microRNAs along with their identified differentially expressed mRNAs were analyzed through microarrays by using integrative systems biology approach. For each cell line miRNA-target gene networks were built, gene ontology and pathway enrichment analyses were performed, enrichment maps were constructed and the potential key genes, microRNAs and microRNA-gene interactions were studied.
Citation Formats
E. Sakallı Tecim, “Integrated analyses of Emodin in breast cancer cell lines,” Ph.D. - Doctoral Program, Middle East Technical University, 2023.