Integrated analyses of Emodin in breast cancer cell lines

Date

2023-6

Author

Sakallı Tecim, Elif

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Breast cancer has been among the most prominent cancers with high incidence rates and mortality. Currently most of the offered therapeutics for treatment are toxic; hence, less toxic therapeutic intervention is required. Here, we studied the molecular mechanisms of the effect of a phytoestrogen Emodin on estrogen receptor positive MCF- 7 and negative MDA-MB-231 cells by carrying out a comprehensive network assessment. Differentially expressed microRNAs along with their identified differentially expressed mRNAs were analyzed through microarrays by using integrative systems biology approach. For each cell line miRNA-target gene networks were built, gene ontology and pathway enrichment analyses were performed, enrichment maps were constructed and the potential key genes, microRNAs and microRNA-gene interactions were studied.

Subject Keywords

Breast cancer, Phytoestrogen, Emodin, miRNA-mRNA integrated analysis, Systems biology

URI

https://hdl.handle.net/11511/104459

Collections

Graduate School of Natural and Applied Sciences, Thesis