Variability of Premature Ventricular Contraction Localization with Respect to Source and Forward Model Variation in Clinical Data

Date

2022-01-01

Author

Rasoolzadeh, Nika
Svehlikova, Jana
Ondrusova, Beata
Serinağaoğlu Doğrusöz, Yeşim

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Objective: Electrocardiographic imaging can provide preliminary locations of premature ventricular contraction (PVC) origins, which can lead to the shortening of the invasive radio-frequency ablation (RFA) procedure. However, PVC localization results vary significantly with respect to the equivalent cardiac source models and the level of complexity assumed in the forward model. This study aims to evaluate PVC localization based on different source and forward model assumptions. Methods: We use body surface potential (BSP) measurements from 5 patients with PVCs, indicated for RFA. Two equivalent source models (dipole-based and heart surface potential-based), and homogeneous and inhomogeneous torso geometries are used to evaluate the variability in the PVC origin. Results: Dipole-based PVC locations are in general more clustered than potential-based ones. Spatio-temporal AT estimates smooth the ATs improving the PVC localizations to be more clustered. Potential-based solutions were more sensitive to changes in the forward model than the dipole-based method. Conclusion: The AT and RRE maps provided similar information consistent with patient descriptions. Therefore, rather than specifying a single point PVC origin, these maps could guide the physicians for more accurate PVC localization.

URI

https://hdl.handle.net/11511/107629

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Department of Electrical and Electronics Engineering, Conference / Seminar