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Asymmetric Synthesis of Trifluoromethyl Substituted Spiro[Indoline‐3,4′‐Pyrano[2,3‐c]Pyrazole] Derivatives with Organocatalysts
Date
2024-02-01
Author
Özcan, Bilge Deniz
Kömüşdoğan, Ezgi Bayer
Şahin, Ertan
Tanyeli, Cihangir
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Spirocyclic compounds have always attracted attention due to their presence as a structural core in a wide variety of natural and bioactive molecules and to exhibit pharmaceutical proper ties. An asymmetric synthesis of spiro[indoline-3,4’-pyrano[2,3- c]pyrazoles] via Michael addition of trifluoromethyl substituted pyrazolone to isatylidene ethyl cyanoacetate derivatives was conducted with excellent enantioselectivities up to 99% and up to 97% isolated yield at room temperature with using 2 mol% of bifunctional quinine derived squaramide organocatalysts.
URI
https://hdl.handle.net/11511/108591
Journal
CHEMISTRYSELECT
DOI
https://doi.org/10.1002/slct.202304275
Collections
Department of Chemistry, Article
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BibTeX
B. D. Özcan, E. B. Kömüşdoğan, E. Şahin, and C. Tanyeli, “Asymmetric Synthesis of Trifluoromethyl Substituted Spiro[Indoline‐3,4′‐Pyrano[2,3‐c]Pyrazole] Derivatives with Organocatalysts,”
CHEMISTRYSELECT
, vol. 9, pp. 1–10, 2024, Accessed: 00, 2024. [Online]. Available: https://hdl.handle.net/11511/108591.