Department of Chemistry, Article

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Recent Submissions

Highly conjugated visible and near-infrared light photoinitiating systems for radical and cationic polymerizations
Suerkan, Ali; Aydan Alkan, Ecem; Kaya, Kerem; Udum, Yasemin; Toppare, Levent Kamil; Yağcı, Yusuf (2021-05-01)
In this communication, we report highly conjugated thiophenes having [1,2,5]-thiadiazolo and [1,2,5]-selenadiazolo [3,4-f]-benzo [1,2,3] triazole in conjunction with diphenyliodonium hexafluorophosphate salt(DPI) as new vi...
Highly-sensitive and fast detection of human telomeric G-Quadruplex DNA based on a hemin-conjugated fluorescent metal-organic framework platform
Javan Kouzegaran, Vahid; Farhadi, Khalil; Forough, Mehrdad; Bahram, Morteza; Persil Çetinkol, Özgül (Elsevier BV, 2021-04-15)
© 2021 Elsevier B.V.The formation of G-quadruplex (G4) structures in Human telomeric DNA (H-Telo) has been demonstrated to inhibit the activity of telomerase enzyme that is associated with the proliferation of many cancer ...
Ultimate COVID-19 Detection Protocol Based on Saliva Sampling and qRT-PCR with Risk Probability Assessment.
Won, Joungha; Kazan, Hasan Hüseyin; Kwon, Jea; Park, Myungsun; Ergun, Mehmet Ali; Özcan Kabasakal, Süreyya; Choi, Byung Yoon; Heo, Won Do; Lee, C Justin (2021-02-28)
In the era of COVID-19 outbreak, various efforts are undertaken to develop a quick, easy, inexpensive, and accurate way for diagnosis. Although many commercial diagnostic kits are available, detailed scientific evaluation ...
The synthesis of chiral β-naphthyl-β-sulfanyl ketones via enantioselective sulfa-Michael reaction in the presence of a bifunctional cinchona/sulfonamide organocatalyst
Tözendemir, Deniz; Tanyeli, Cihangir (2021-02-01)
Cinchona alkaloid-derived organocatalysts are widely employed in various asymmetric transformations, yielding products with high enantiopurity. In this respect, a bifunctional quinine-derived sulfonamide organocatalyst was...
Iron-Catalyzed α-C-H Cyanation of Simple and Complex Tertiary Amines.
Yilmaz, Ozgur; Dengiz, Çağatay; Emmert, Marion H (American Chemical Society (ACS), 2021-01-19)
This manuscript details the development of a general and mild protocol for the α-C–H cyanation of tertiary amines and its application in late-stage functionalization. Suitable substrates include tertiary aliphatic, benzyli...
Indenoquinoxalinone based conjugated polymer substrate for laccase biosensor
Cevher, Şevki Can; Çırpan, Ali; Bekmezci, Sıddıka Aybüke; Soylemez, Saniye; Udum, Yasemin Arslan; Toppare, Levent Kamil (Elsevier BV, 2021-01-01)
This paper describes the synthesis and characterization of a novel monomer (6,9-bis(4-hexylthiophen-2-yl)-11H-indeno[2,1-b]quinoxalin-11-one (M1)). M1 monomer was electrochemically polymerized on the electrode surface and ...
A machine learning algorithm to differentiate bipolar disorder from major depressive disorder using an online mental health questionnaire and blood biomarker data
Tomasik, Jakub; Han, Sung Yeon Sarah; Barton-Owen, Giles; Mirea, Dan-Mircea; Martin-Key, Nayra A.; Rustogi, Nitin; Lago, Santiago G.; Olmert, Tony; Cooper, Jason D.; Özcan Kabasakal, Süreyya; Eljasz, Pawel; Thomas, Gregoire; Tuytten, Robin; Metcalfe, Tim; Schei, Thea S.; Farrag, Lynn P.; Friend, Lauren V.; Bell, Emily; Cowell, Dan; Bahn, Sabine (2021-01-01)
The vast personal and economic burden of mood disorders is largely caused by their under- and misdiagnosis, which is associated with ineffective treatment and worsening of outcomes. Here, we aimed to develop a diagnostic a...
Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patients
Bojko, Barbara; Vasiljevic, Tijana; Boyacı, Ezel; Roszkowska, Anna; Kraeva, Natalia; Moreno, Carlos A. Ibarra; Koivu, Annabel; Wasowicz, Marcin; Hanna, Amy; Hamilton, Susan; Riazi, Sheila; Pawliszyn, Janusz (Springer Science and Business Media LLC, 2021-01-01)
Purpose Malignant hyperthermia (MH) is a potentially fatal hypermetabolic condition triggered by certain anesthetics and caused by defective calcium homeostasis in skeletal muscle cells. Recent evidence has revealed impair...
Doxorubicin exhibits strong and selective association with VEGF Pu22 G-quadruplex
Bilgen, Ecenaz; Persil Çetinkol, Özgül (Elsevier BV, 2020-12-01)
Background: Vascular endothelial growth factor (VEGF), is upregulated in tumor cells and thus became a potential therapeutic target for anti-cancer drugs. Recent reports suggested the use of Doxorubicin (Dox) with VEGF-tar...
Core/shell type, Ce3+ and Tb3+ doped GdBO3 system: Synthesis and Celecoxib drug delivery application
Çolak, Pelin; Ulusan, Sinem; Banerjee, Sreeparna; Yılmaz, Ayşen (Elsevier BV, 2020-12-01)
In this study, luminescent and magnetic core/shell Gd1-x-yCexTbyBO3@SiO2 nanoparticles were synthesized and used to design a drug delivery system for Celecoxib (CLX). CLX was chosen as the model drug because it is a nonste...
Resorufin Enters the Photodynamic Therapy Arena: A Monoamine Oxidase Activatable Agent for Selective Cytotoxicity
Almammadov, Toghrul; Atakan, Gizem; Leylek, Ozen; Ozcan, Gulnihal; Günbaş, Emrullah Görkem; Kolemen, Safacan (2020-12-01)
A red-absorbing, water-soluble, and iodinated resorufin derivative (R1) that can be selectively activated with a monoamine oxidase (MAO) enzyme was synthesized, and its potential as a photodynamic therapy (PDT) agent was e...
Synthesis, characterization, and theoretical investigation of optical and nonlinear optical (NLO) properties of triazene-based push–pull chromophores
Mammadova, Flora; Ozsinan, Semin; Okutan, Merve; Dengiz, Çağatay (Elsevier BV, 2020-11-15)
A short and efficient synthetic strategy for the synthesis of triazene-substituted push–pull dyes has been developed. The formal [2 + 2] cycloaddition-retroelectrocyclization was utilized for the preparation of the target ...
Effect of fluorine substituted benzothiadiazole on electro-optical properties of donor-acceptor-donor type monomers and their polymers
Çakal, Deniz; Ercan, Yunus Emre; Önal, Ahmet Muhtar; CİHANER, ATİLLA (Elsevier BV, 2020-11-01)
A series of trimeric monomers bearing thiophene donor units and fluorinated analogues of benzothiadiazole acceptor units was synthesized via donor-acceptor-donor approach and polymerized electrochemically in order to inves...
A biosensor platform based on amine functionalized conjugated benzenediamine-benzodithiophene polymer for testosterone analysis
BULUT, Umut; ŞANLI, SERDAR; Cevher, Sevki Can; Çırpan, Ali; Donmez, Sude; TİMUR, SUNA (Wiley, 2020-11-01)
A novel benzenediamine‐benzodithiophene polymer is synthesized for use in biosensor fabrication for the detection of testosterone. The sensory platform is constructed via drop coating on a screen‐printed carbon electrode, ...
Diagnostic prediction model development using data from dried blood spot proteomics and a digital mental health assessment to identify major depressive disorder among individuals presenting with low mood.
Han, SYS; Tomasik, J; Rustogi, N; Lago, SG; Barton-Owen, G; Eljasz, P; Cooper, JD; Özcan Kabasakal, Süreyya; Olmert, T; Farrag, LP; Friend, LV; Bell, E; Cowell, D; Thomas, G; Tuytten, R; Bahn, S (Elsevier BV, 2020-11-01)
With less than half of patients with major depressive disorder (MDD) correctly diagnosed within the primary care setting, there is a clinical need to develop an objective and readily accessible test to enable earlier and m...
Influence of hydrogen bond on the mesomorphic behaviour in urethane based liquid crystalline compounds: Experimental and computer simulation study
Korkmaz, Burak; Agtas, Sinem; Sutay, Berkay; Yıldırım, Erol; Yilgor, Iskender; Yurtsever, Mine; Şenkal, Bahire Filiz; Gürsel, Yeşim (Elsevier BV, 2020-11-01)
We present a combined experimental and theoretical study on the novel hydrogen-bonded liquid crystalline complex (UR-LC11) exhibiting both nematic and smectic phases upon cooling. The complex was prepared by mixing 2-(2-me...
The synthesis of peptide-conjugated poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PEtOx-b-PLA) polymeric systems through the combination of controlled polymerization techniques and click reactions
Ozkose, Umut Ugur; Gulyuz, Sevgi; Parlak Khalily, Melek; Özçubukçu, Salih; BOZKIR, ASUMAN; TAŞDELEN, MEHMET ATİLLA; Alptürk, Onur; Yilmaz, Ozgur (2020-11-01)
To optimize the therapeutic effect of pharmaceutical agents, drug delivery systems tailored from FDA-approved polymers like poly(L-lactide) (PLA) is an effective strategy. Because of their hydrophobic character, these syst...
A new approach for the synthesis of spiro and gem-dimethyl-substituted 1,4-oxazepines from N-propargylic beta-enaminones
Karadeniz, Eda; Kelgökmen, Yılmaz; Zora, Metin (Wiley, 2020-11-01)
An efficient and general method for the synthesis of spiro-1,4-oxazepines and 3,3-dimethyl-1,4-oxazepines is reported. When treated with ZnI2 and AgSbF6 in refluxing DCE, cyclohexane-embedded N-propargylic beta-enaminones ...
Chiral Polyurea from Tartaric Acid Derived and Lysine Backbone: A Synthetic and Computational Study
Ünay, Gizem; Yıldırım, Erol; Akdağ, Akın (2020-11-01)
In recent years, the studies on artificial helical polymers have become an attractive field due to their impressive optical activity and functions. They have numerous potential applications in many areas such as chiral rec...
A facile synthesis of 6-chloro-2-methylene-2,3-dihydro-1,4-oxazepines from N-propargylic beta-enaminones
Ibis, Ozge; Zora, Metin (Elsevier BV, 2020-11-01)
A new and efficient method for the synthesis of 6-chloro-substituted 2-methylene-2,3-dihydro-1,4-oxazepines has been demonstrated. Upon treatment with N-chlorosuccinimide in acetonitrile, N-propargylic beta-enaminones unde...