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Push–pull chromophores for rapid cancer detection via smartphone-based tumor microenvironment sensing Yilmaz, Ilayda; Moulahoum, Hichem; Erden, Kübra; Yıldırım, Erol; Tok, Kerem; Aksu, Didem; Akcam, Tevfik Ilker; Zihnioğlu, Figen; Turhan, Kutsal; Dengiz, Çağatay; Soylemez, Saniye; Timur, Suna (2026-12-01) Smartphone-based imaging offers a low-cost and portable point-of-care solution to meet the need for simple tools enabling rapid and accessible detection of biochemical alterations in the tumor microenvironment (TME). In th...
Access to NLO-active donor–acceptor-type spiro compounds via cascade reactions of 3-alkynylindoles and DDQ Ismail, Mahmoud F.; Ekiz, Yasemin; Erden, Kübra; Şahin, Onur; Esenturk, Okan; Dengiz, Çağatay (2026-11-01) In this study, five homoconjugated NLOphore candidates decorated with indole donor groups were synthesized in 55–85% yields via click-type formal [2+2] cycloaddition reactions. The obtained compounds were subse- quently tr...
Incorporation of a π-bridge in triphenylamine-EDOT based conjugated polymer for bifunctional electrochromic supercapacitor device Keserci, Arya Zelal; Arabacı, Elif Demir; Karakurt, Oğuzhan; Maraslioglu, Cem; Baran, Eminenur; Cevher, Duygu; Çırpan, Ali (2026-10-20) The development of multifunctional electrode materials that simultaneously exhibit electrochromic and capacitive behavior is increasingly important for next-generation energy storage and smart optoelectronic systems. In th...
Influence of ions, pH and crowding agents on structure and stability of PIM1 secondary structures Göller, İrem; Orouji, Saba; Persil Çetinkol, Özgül (2026-08-01) Triple Negative Breast Cancer (TNBC) is an aggressive subtype of breast cancer defined by the absence of ER, PR and HER-2 receptors. The lacking of these receptors limits the availability of the targeted therapy options. T...
Furan, Selenophene, and Thiophene-Bridged Triphenylamine Polymer Films: A Systematic Chalcogen Study of Bifunctional Electrochromic Supercapacitor Electrodes Keserci, Arya Zelal; Hosseini, Shadi; Karakurt, Oğuzhan; Toppare, Levent Kamil; Çırpan, Ali (2026-08-01) Bifunctional electrochromic supercapacitor devices (ESD), which integrate electrochromic and pseudocapacitive functionalities within a single electrode material, have emerged as a promising platform for intelligent energy ...
Leucine Aminopeptidase-Activatable Photosensitizer Enables Enzyme-Responsive Photodynamic Therapy in Neuroblastoma Karaman, Osman; Kepil, Dilay; Sayin, Asena; Forough, Mehrdad; Ozkan, Erva; Elmazoglu, Zubeyir; Günbaş, Emrullah Görkem (2026-06-03) Photodynamic therapy (PDT) is a minimally invasive and tumor-selective treatment modality; however, despite notable progress in several cancer types, effective treatment options for brain tumors remain limited. Although ex...
Copper-Catalyzed Domino Strategy Construction of Fused Benzopyrroloazepinone through the Reaction of Allenyloximes and Arylboronic Acids Ejiyeh, Negah Esnaashari; Amiri, Kamran; Bijarkani, Fatemeh Hadizadeh; Hosseini, S. Sina; Fouladi, Vahid; Fathi, Azar; Bijanzadeh, Hamid Reza; Rominger, Frank; Tanyeli, Cihangir; Balalaie, Saeed (2026-06-01) Herein, we present a novel strategy for the efficient synthesis of fused azepinone frameworks from allene-tethered oximes and arylboronic acids through a domino effect comprising a Chan-Lam coupling, [3 + 2] cycloaddition,...
Sludge disintegration methods, their impact on additives leaching from microplastics and change in plastic properties Cemalgil, Nermin; Ayça, İpek; Karakurt, Ozan; Erel Göktepe, İrem; Ertaş, Gülay; Sanin, Faika Dilek (2026-06-01) The significant accumulation of microplastics (MPs) in wastewater sludge poses a potential risk to the efficiency and stability of anaerobic digestion (AD). While sludge disintegration methods are commonly used to enhance ...
A Hydroxy-Substituted Trialkyloxonium Ion and Its Oxonium Alkoxide Zwitterion Otsuki, Andrew L.; Alkan, Gizem Atakan; Manabe, Shuhei; Shewa, Wondimagegn T.; Günbaş, Emrullah Görkem; Fettinger, James C.; Mascal, Mark; Hafezi, Nema (2026-05-11) Trialkyl oxonium salts are among the most powerful electrophiles known. They are immediately quenched by nucleophiles like alcohols and halide ions, and are therefore used in unreactive solvents and have non-nucleophilic c...
Rapid Access to 1,2,3,4-Tetrasubstituted Benzenes and 3-Alkenyl-1,2-dihydropyridines DÜNDAR ÖZDOĞAN, BUSE AYŞEN; Zora, Metin (2026-05-04) Herein, we report unprecedented protocols for the synthesis of 1,2,3,4-tetrasubstituted benzenes and 3-alkenyl-1,2-dihydropyridines from readily available N-methyl-N-propargyl beta-enaminones. When subjected to the reactio...
Selenium-Bearing Conducting Polymer/Graphene Quantum Dot Hybrid for Enzyme Based Electrochemical Biosensor Targeting Tyrosinase Inhibition Via Rosmarinic Acid Alhardan, Raghad; Keles, Gulsu; Cevher, Şevki Can; ALTAY, DERYA; Kalligosfyri, Panagiota M.; Erdem, Sinem Aslan; Çırpan, Ali; Cinti, Stefano; KURBANOĞLU, SEVİNÇ (2026-05-01) In this present study, an enzyme-based amperometric nanobiosensor was designed and fabricated through the immobilization of tyrosinase onto a selenium-bearing conducting polymer (poly[BDT-alt-(TP;BSe)]), in combination wit...
Activatable Silicon-Xanthene Photosensitizer for Photodynamic Therapy of Glioblastoma Karaman, Osman; Kepil, Dilay; FOROUGH, MEHRDAD; Elmazoglu, Zubeyir; Günbaş, Emrullah Görkem (2026-04-01) Background: Photodynamic therapy (PDT) offers a promising complementary strategy for treating glioblastoma multiforme (GBM); however, limited control over photosensitizer activation and reduced efficacy under hypoxic condi...
Computational investigation of diphenyl sulfone based thermally activated delayed fluorescence materials and their optoelectronic properties. Dastemir, Murat; Gürsöz, Ekinsu; Yıldırım, Erol (2026-03-18)
Matrix-Dependent Effects of Phytic Acid on Konjac Glucomannan and Hyaluronic Acid Films for Biomedical Applications Zasada, Lidia; Gençer, İpek; Chmielniak, Dorota; Brzezinska, Maria Swiontek; Wróbel, Monika; Dembińska, Katarzyna; Sobiepanek, Anna; D'Amora, Ugo; Kaczmarek-Szczepańska, Beata (2026-03-01) Chronic wounds and bacterial infections present significant challenges in tissue regeneration, demanding the development of advanced bioactive materials that balance biocompatibility, antimicrobial activity, and tunable ph...
Computational investigation of diphenyl sulfone based thermally activated delayed fluorescence materials and their optoelectronic properties Dastemir, Murat; Gürsöz, Ekinsu; Yildirim, Erol (Elsevier BV, 2026-3)
Battery-Free Near Field Communication (NFC)-Assisted Advanced Ethanol Sensing Platform Based on Conjugated Polymer Nanoparticles OSMANOĞULLARI, SILA CAN; Soyler, Dilek; Varlioglu Yaylali, Figen; Karabag, Aliekber; Yeniterzi, Dilara; Timur, Suna; Günbaş, Emrullah Görkem; Soylemez, Saniye (2026-01-23) The incorporation of biorecognition elements with electronic components into point-of-care testing (POCT) devices expands their capabilities and enables intricate quantitative assays. The combination of near field communic...
Liquid-assisted ball-milling synthesis of organic carbonates as aroma compounds Bozdemir, Can; Çelik, Mehmet Efe; Mart, Mehmet; Alemdar, Aydın; Baydar, Ahmet; Dengiz, Çağatay (2026-01-01) A new approach based on ball milling is introduced as an efficient and greener alternative to conventional solution-based methods for the synthesis of carbonate compounds, which typically require toxic solvents (e.g., dich...
Evaluation of chemical and rheological properties of warm mix asphalt binders considering binder source, additive type, and aging Yildirim, Semiha Uhde; Tanyeli, Cihangir; Güler, Ali Murat; Öztürk, Hande Işık (2026-01-01) Warm mix asphalt (WMA) technologies have long been used without compromising the performance of asphalt concrete. However, no research has yet investigated the chemo-mechanisms of WMA-modified binders considering the effec...
Exploring Microencapsulated Magnesium Tetraborate: A Promising Flame-Retardant Additive for Polyurethane-Based Composites Çelik, Muzaffer Gencay; Tayfun, Ümit; DOĞAN, MEHMET; Yılmaz, Ayşen (2026-01-01) Boron compounds exhibit low toxicity and diverse molecular structures, rendering them effective flame-retardant additives in polymer-based materials through various mechanisms of action. Magnesium tetraborate (MTB) and mel...
Facile one-pot synthesis of 5-alkylidene-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridines Korkmaz, Esra; Zora, Metin (2026-01-01) A straightforward and efficient one-pot protocol for the synthesis of 5-alkylidene-2,3,5,6,7,8-hexahydroimidazo[1,2-a]pyridines is reported. When subjected to reaction with ethylenediamine in refluxing dioxane, bis-α,β-alk...

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