Asymmetric aza-Henry reaction of BOC-protected imines with zinc-FAM catalyst

Date

2024-01-01

Author

Beksultanova, Nurzhan
Doğan, Özdemir

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Derivatives of ferrocenyl-substituted aziridinyl methanol (FAM) ligands were used with zinc metal for asymmetric aza-Henry (nitro-aldol) reaction of N-Boc protected imines with nitroalkanes. At optimized reaction conditions Zn-PFAM1 catalyst system with a variety of aromatic imines provided products in up to 77% ee and 88% yield. In addition, the reaction of N-Boc substituted imines with nitroethane also proceeded smoothly with moderate enantioselectivities and diastereoselectivities.

Subject Keywords

asymmetric nitroaldol reaction, aza-Henry reaction, N-BOC imines, nitroethane

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85182464694&origin=inward
https://hdl.handle.net/11511/108644

Journal

Synthetic Communications

DOI

https://doi.org/10.1080/00397911.2024.2303054

Collections

Department of Chemistry, Article

Citation Formats

N. Beksultanova and Ö. Doğan, “Asymmetric aza-Henry reaction of BOC-protected imines with zinc-FAM catalyst,” Synthetic Communications, vol. 54, no. 5, pp. 371–378, 2024, Accessed: 00, 2024. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85182464694&origin=inward.