Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Designing Non-Invasive Quality Control Methods for Pharmaceutical Drugs
Download
Hani ALAM - Ph.D. Dissertation.pdf
Date
2024-3-11
Author
ALAM, Hani
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
51
views
0
downloads
Cite This
The quality of pharmaceutical products is a critical aspect of the pharmaceutical industry that attempts to ensure that they meet the required safety and efficacy standards. Quality control ensures that these products are safe and meet the requirements of the regulators and government agencies. The main objective of quality control is to identify and quantify active substances and track impurities using analytical techniques, such as high-performance liquid chromatography (HPLC). However, many of these techniques are time consuming, destructive to samples, damaging to the environment, and expensive to operate and maintain. This study aims to use alternative methods for quality control that are easy to operate, affordable, eco-friendly, and non-destructive to samples. This study examined near infrared spectroscopy (NIRS) and time-domain nuclear magnetic resonance (TD-NMR) in order to produce non-destructive methods for three different quality control issues. The first part of this study focused on measuring the mixture ratios of two different insulin drugs and succeeded by integrating two different TD-NMR techniques. The second part measured the degradation of aspirin to salicylic acid using NIRS and TD-NMR. The third part involved the use of bovine serum albumin as a model drug for biopharmaceuticals. Later, glycation was applied and measured using different TD-NMR techniques to be compared with browning measurements and the O-phthalaldehyde (OPA) method, which are two parameters used to measure glycation. This dissertation has demonstrated that TD-NMR and NIRS are valuable and useful methods for various pharmaceutical quality control procedures as more affordable, eco-friendly, and user-friendly alternatives to the current destructive chemical and chromatographic techniques.
Subject Keywords
Aspirin
,
Insulin mixtures
,
Glycation
,
Time-Domain Nuclear Magnetic Resonance (TD-NMR)
,
Near Infrared Spectrometry (NIRS)
,
Pharmaceutical Quality Control
URI
https://hdl.handle.net/11511/109215
Collections
Graduate School of Natural and Applied Sciences, Thesis
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
H. ALAM, “Designing Non-Invasive Quality Control Methods for Pharmaceutical Drugs,” Ph.D. - Doctoral Program, Middle East Technical University, 2024.