Asymmetric synthesis of chiral bidentate ligands

Özçubukçu, Salih


Asymmetric synthesis of alpha-amino-alpha-arylphosphonic acids via the reduction of aroyl phosphonate O-benzyl oxime ethers
Demir, Ayhan Sıtkı (1996-08-25)
Asymmetric synthesis of chiral camphor fused pyridine type novel organocatalysts
Küçükdişli, Murat; Tanyeli, Cihangir; Department of Chemistry (2009)
Chiral pyridines as organocatalysts have been used in asymmetric organic synthesis in recent years. The asymmetric synthesis of camphor fused pyridine type novel organocatalysts were perfomed starting from cheap and easily available natural (+)-camphor. Using camphor fused pyridine skeleton, six organocatalysts 29, 32, 33, 38, 40, and 41were successfully synthesized. The first four nucleophilic and Lewis base catalysts 29, 32, and 33 are different P-oxides and P,N-dioxides which were tested in allylation of...
Asymmetric synthesis of 2,3-dihydrofurans with bifunctional quinine / squaramide organocatalysts
Bozdemir, Merve; Tanyeli, Cihangir; Department of Chemistry (2019)
Organocatalytic asymmetric reactions are efficient and environmentally friendly methods to synthesize products with higher enantioselectivities. Asymmetric domino Michael-SN2 reactions are one of the type of organocatalytic reaction frequently used to form carbon-carbon bonds in the synthesis of the derivatives of dihydrofurans, which are intermediates mainly utilized as precessor materials in the pharmaceutical fields. In this thesis, the reaction occuring between acetylacetone and (Z)-(2-bromo-2-nitroviny...
Asymmetric synthesis of tetrahydrothiophenes in the presence of bifunctional organocatalysts
Tümer, Mustafa Faik; Tanyeli, Cihangir; Department of Chemistry (2021-1-22)
In general, nitroolefins are convenient structures as Michael acceptors. To make it clear for this work, attack of a sulfur-containing nucleophile to a nitroolefin forms a C-S bond and opening the double bond would create a nucleophilic center on the nitroolefin which leads to the formation of a new C-C bond. In this study, asymmetric organocatalytic sulfa-Michael addition of 1,4-dithiane-2,5-diol to trans-β-nitrostyrene derivatives was carried out which yielded polyfunctional tetrahydrothiophenes that have...
Asymmetric Michael addition of aldehydes to nitroolefins with l-proline and bifunctional organocatalyst combination
İşibol, Duygu; Demir, Ayhan Sıtkı; Tanyeli, Cihangir; Department of Chemistry (2013)
Since their serendipitously discovery in 1993, hydrogel of self-assembling peptides are becoming an emerging field especially in last 10 years. For their application in selective drug delivery, tissue engineering and biomedical applications, divergent peptide libraries can be constructed through chemical peptide synthesis, utilizing synthetic amino acids addition to 21 naturally occurring ones. One of the methods which were applied to obtain self-assembling peptides is incorporating strongly beta-sheet form...
Citation Formats
S. Özçubukçu, “Asymmetric synthesis of chiral bidentate ligands,” Middle East Technical University, 2002.