Transformation of cyclohexanone derivatives to bicyclic furan and pyrrole derivatives

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2004
Yazıcıoğlu, Emre Yusuf
Tetrahydrobenzofurans and tetrahydroindoles are two very valuable classes of substances which have wide usage area; either as starting materials for drug substances or many other compounds which have fused heterocyclic rings in their structures and pharmacophore for many complex natural products; syntheses of derivatives of these compounds with different substitution patterns, is an exciting challenge for many scientists. Benzofuran and tetrahydroindole derivatives, which are potent bioactive substances, are synthesized from various cyclohexanone derivatives that are allylated by Stork-enamine or Mn(OAc)3 mediated allylation methods. Allylated ketones are later transformed to benzofuran derivatives upon treatment with base or tetrahydroindole derivatives upon treatment with primary amines.

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Citation Formats
E. Y. Yazıcıoğlu, “Transformation of cyclohexanone derivatives to bicyclic furan and pyrrole derivatives,” M.S. - Master of Science, Middle East Technical University, 2004.