A survey of available tools and web servers for analysis of protein-protein interactions and interfaces

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2009-05-01

Author

Tunçbağ, Nurcan
Keskin, Ozlem
Gursoy, Attila
NUSSINOV, Ruth

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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The unanimous agreement that cellular processes are (largely) governed by interactions between proteins has led to enormous community efforts culminating in overwhelming information relating to these proteins; to the regulation of their interactions, to the way in which they interact and to the function which is determined by these interactions. These data have been organized in databases and servers. However, to make these really useful, it is essential not only to be aware of these, but in particular to have a working knowledge of which tools to use for a given problem; what are the tool advantages and drawbacks; and no less important how to combine these for a particular goal since usually it is not one tool, but some combination of tool-modules that is needed. This is the goal of this review.

Subject Keywords

Protein-protein interactions, Protein-protein interfaces, Binding site prediction, Docking, Web servers, Databases

URI

https://hdl.handle.net/11511/31146

Journal

BRIEFINGS IN BIOINFORMATICS

DOI

https://doi.org/10.1093/bib/bbp001

Collections

Graduate School of Informatics, Article

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Citation Formats

N. Tunçbağ, O. Keskin, A. Gursoy, and R. NUSSINOV, “A survey of available tools and web servers for analysis of protein-protein interactions and interfaces,” BRIEFINGS IN BIOINFORMATICS, pp. 217–232, 2009, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31146.