Synthesis and Rhizopus oryzae mediated enantioselective hydrolysis of α-acetoxy aryl alkyl ketones

Date

1998-05-22

Author

Demir, Ayhan Sıtkı
Hamamcı, Haluk
Tanyeli, Cihangir
Akhmedov, Idris M.
DOGANEL, Fatos

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Mn(OAc)(3) oxidation of aromatic ketones afforded the alpha-acetoxy ketones in good yield. Selective hydrolysis of the acetoxy ketones by the fungus Rhizopus oryzae yields (R)-hydroxy ketones in high enantiomeric excess.

Subject Keywords

Manganese(iii) acetate, Asymmetric oxidation, Carboxylic-acids, Bakers-yeast, Stereochemistry, Hydroxylation, Combination, Resolution, Chemistry, Alcohols

URI

https://hdl.handle.net/11511/32186

Journal

Tetrahedron Asymmetry

DOI

https://doi.org/10.1016/s0957-4166(98)00165-7

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

A. S. Demir, H. Hamamcı, C. Tanyeli, I. M. Akhmedov, and F. DOGANEL, “Synthesis and Rhizopus oryzae mediated enantioselective hydrolysis of α-acetoxy aryl alkyl ketones,” Tetrahedron Asymmetry, pp. 1673–1677, 1998, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32186.