A Revertible, Autonomous, Self-Assembled DNA-Origami Nanoactuator

Date

2011-12-01

Author

MARİNİ, Monica
Piantanida, Luca
Musetti, Rita
Bek, Alpan
Dong, Mingdong
Besenbacher, Flemming
Lazzarino, Marco
Firrao, Giuseppe

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A DNA-origami actuator capable of autonomous internal motion in accord to an external chemical signal was designed, built, operated and imaged. The functional DNA nanostructure consists of a disk connected to an external ring in two, diametrically opposite points. A single stranded DNA, named probe, was connected to two edges of the disk perpendicularly to the axis of constrain. In the presence of a hybridizing target molecule, the probe coiled into a double helix that stretched the inner disk forcing the edges to move toward each other. The addition of a third single stranded molecule that displaced the target from the probe restored the initial state of the origami. Operation, dimension and shape were carefully characterized by combining microscopy and fluorescence techniques.

Subject Keywords

DNA origami, Actuation, Reusable, Autonomous switch, Self-assembly

URI

https://hdl.handle.net/11511/37785

Journal

NANO LETTERS

DOI

https://doi.org/10.1021/nl203217m

Collections

Department of Physics, Article

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Citation Formats

M. MARİNİ et al., “A Revertible, Autonomous, Self-Assembled DNA-Origami Nanoactuator,” NANO LETTERS, pp. 5449–5454, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37785.