Show/Hide Menu
Hide/Show Apps
anonymousUser
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Videos
Videos
Thesis submission
Thesis submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Contact us
Contact us
KCl-induced cortical spreading depression waves more heterogeneously propagate than optogenetically-induced waves in lissencephalic brain: an analysis with optical flow tools
Download
10.1038:s41598-020-69669-6.pdf
Date
2020-07-01
Author
Donmez-Demir, Buket
ERDENER, ŞEFİK EVREN
KARATAŞ KURŞUN, HÜLYA
Kaya, Zeynep
Ulusoy, İlkay
DALKARA, TURGAY
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
18
views
14
downloads
Cite This
Although cortical spreading depolarizations (CSD) were originally assumed to be homogeneously and concentrically propagating waves, evidence obtained first in gyrencephalic brains and later in lissencephalic brains suggested a rather non-uniform propagation, shaped heterogeneously by factors like cortical region differences, vascular anatomy, wave recurrences and refractory periods. Understanding this heterogeneity is important to better evaluate the experimental models on the mechanistics of CSD and to make appropriate clinical estimations on neurological disorders like migraine, stroke, and traumatic brain injury. This study demonstrates the application of optical flow analysis tools for systematic and objective evaluation of spatiotemporal CSD propagation patterns in anesthetized mice and compares the propagation profile in different CSD induction models. Our findings confirm the asymmetric angular CSD propagation in lissencephalic brains and suggest a strong dependency on induction-method, such that continuous potassium chloride application leads to significantly higher angular propagation variability compared to optogenetically-induced CSDs.
Subject Keywords
Multidisciplinary
,
SPATIOTEMPORAL DYNAMICS
,
DEPOLARIZATION
,
CORTEX
URI
https://hdl.handle.net/11511/47997
Journal
SCIENTIFIC REPORTS
DOI
https://doi.org/10.1038/s41598-020-69669-6
Collections
Department of Electrical and Electronics Engineering, Article
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
B. Donmez-Demir, Ş. E. ERDENER, H. KARATAŞ KURŞUN, Z. Kaya, İ. Ulusoy, and T. DALKARA, “KCl-induced cortical spreading depression waves more heterogeneously propagate than optogenetically-induced waves in lissencephalic brain: an analysis with optical flow tools,”
SCIENTIFIC REPORTS
, vol. 10, no. 1, pp. 0–0, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/47997.