Fam ve pfam kiral ligandları ile organik bileşiklerin katalitik enantioseçici sentezi

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2012

Author

Bulut, Adnan
Doğan, Özdemir
İşçi, Muhammet
Tecimer, Ali Muhammet
Aksakal, Duygu
Çağlı, Eda

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Doğada bulunan bir çok bileşik (amino asitler, şekerler, steroidler, alkoloidler gibi) kiraldir. Bu bileşiklerin bir kısmı doğrudan ilaç bir kısmıda ilaç hammaddesi olarak kullanılmaktadır. Bu bileşiklerin asimetrik sentezi için hem çevreci hemde ekonomik olması nedeniyle tercih edilen iki yöntem metal katalizörleri (kiral ligand + metal) ve organokatalizörlerdir. Grubumuz yeni metal katalizörleri ve organokatalizörler geliştirerek organik bileşiklerin asimetrik sentezini gerçekleştirmeye çalışmaktadır. TÜBİTAK tarafından desteklenen bu projede daha önce geliştirilen FAM, PFAM ve yeni geliştirilen POAP kiral bileşikleri ligand veya organokatalizör olarak: Nitroolefinlere nitroetan katılması, aldehitlere trialkil fosfit katılması, aldehitlere allil(trikloro)silan katılması, asimetrik aldol ve sulfonoiliminlere dietilçinko katılması tepkimelerinde denenmiştir. Birinci tepkime dışındaki dört tepkimede beklenen ürünler genelde oldukça iyi verim ve kabul edilebilir enantiseçicilikle elde edilmiştir.

Subject Keywords

Asimetrik sentez, Kiral ligand, Organokatalizör

URI

https://app.trdizin.gov.tr/publication/project/detail/TVRNME9UWTI
https://hdl.handle.net/11511/49544

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Department of Chemistry, Project and Design

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Citation Formats

A. Bulut, Ö. Doğan, M. İşçi, A. M. Tecimer, D. Aksakal, and E. Çağlı, “Fam ve pfam kiral ligandları ile organik bileşiklerin katalitik enantioseçici sentezi,” 2012. Accessed: 00, 2020. [Online]. Available: https://app.trdizin.gov.tr/publication/project/detail/TVRNME9UWTI.