Investigation of multidrug resistance in docetaxel and doxorubicin-resistant MCF-7 cell lines

Date

2006-06-01

Author

Iscri, O. Darcansoy
Kars, M. Demirel
Gündüz, Ufuk
Arpaci, F.

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

98
views

0
downloads

URI

https://hdl.handle.net/11511/53435

Collections

Graduate School of Natural and Applied Sciences, Conference / Seminar

Suggestions

OpenMETU
Core

Investigation of the effect of sodium butyrate on the regulation of cyclooxygenase-2 in colon cancer cell lines Caco-2 and HT-29 Ülgen, Doğukan Hazar; Banerjee, Sreeparna; Department of Biology (2015) Sodium butyrate (NaBt) is a four-carbon short-chain fatty acid histone deacetylase inhibitor (HDACi) that is available in the colon through the commensal microbiota-mediated fermentation of dietary fibers. It is the main source of energy for colonocytes, and is regarded to have tumor suppressive effects, most prominently in colorectal cancer (CRC). Cyclooxygenase-2 (COX-2) is a gene important in the inflammatory response due to its ability to convert arachidonic acid to prostaglandins. Overexpression and ov...
Investigation of docetaxel and doxorubicin resistance in mcf-7 breast carcinoma cell line Darcansoy İşeri, Özlem; Gündüz, Ufuk; Department of Biotechnology (2009) Multidrug resistance phenotype of tumor cells describes resistance to wide range of structurally unrelated anticancer agents and is a serious limitation to effective chemotherapy. It is a multifactor yet not fully elucidated phenomenon by the involvement of diverse cellular pathways. Aim of this study was to investigate the resistance mechanisms developed against docetaxel and doxorubicin that are widely used in the treatment of breast cancer in model cell line MCF-7. Resistant sublines were developed by ap...
Investigation of the lipid metabolic changes induced by novel alpha tocopherol analog (TC6OH) in luminal a type breast cancer cells Gök, Seher; Severcan, Feride; Department of Biology (2017) Although the traditional chemotherapeutic agents able to suppress breast tumor progression, they are mostly unspecific in their mechanism of action and have toxic effects to normal tissues. Instead, it has been reported that tumor cells are more sensitive to some forms of Vitamin E (VE) and its synthetic derivatives than healthy cells. Studies of drug-cell interactions and understanding the mechanism underlying cytotoxic activity and biological effects at molecular level in cancer model cells are essential ...
Investigation of apoptotic gene expression levels in multidrug-resistant MCF-7 cell lines Iseri, O. Darcansoy; Kars, M. Demirel; Gündüz, Ufuk (2006-06-01)
Investigation of the effect of sodium butyrate induced differentiation on inflammatory pathways in colon cancer cells Küçükdemir, Mümine; Banerjee, Sreeparna; Department of Biology (2012) Sodium butyrate (NaBt) is a four-carbon short chain fatty acid, produced naturally in colon as the end product of the bacterial anaerobic metabolism on dietary fibers. It was previously shown that NaBt can induce differentiation and may inhibit proliferation. The objective of this study was to investigate the effect of NaBt-induced differentation on inflammatory pathways in HT29 colon cancer cells. For this purpose, first, cells were treated with varying concentrations of NaBt from 1-5 mM and amount require...

Citation Formats

O. D. Iscri, M. D. Kars, U. Gündüz, and F. Arpaci, “Investigation of multidrug resistance in docetaxel and doxorubicin-resistant MCF-7 cell lines,” 2006, vol. 273, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/53435.