Analysis of microsomal epoxide hydrolase tyr113his and his139ARG genotypes with ischemic stroke risk in Turkish population

Micoogullari, Y.
Eroglu, E.
Ozcelik, A. T.
Demirdogen, B. C.
Akgun, H.
Demirkaya, S.
Adalı, Orhan


Analysis of cytochrome P4501A1 genetic polymorphisms in patients with ischemic stroke
Adalı, Ayşe Çınar; Adalı, Orhan; Demirdöğen, Birsen Can; Department of Biochemistry (2011)
Stroke is the third leading cause of death worldwide and results in serious disabilities. Cytochrome P450 1A1 gene (CYP1A1) is a highly polymorphic gene encoding its corresponding xenobiotic metabolizing enzyme which is responsible from the metabolism of carcinogenic polycyclic aromatic hydrocarbons (PAHs) that are engaged with the formation of free radicals. Atherosclerosis is a major cause of ischemic stroke and this pathology may be associated with the disruption of vascular homeostasis due to the format...
Evaluation of an aldo-keto reductase gene signature with prognostic significance in colon cancer via activation of epithelial to mesenchymal transition and the p70S6K pathway
Canli, Secil Demirkol; Seza, Esin Gulce; Sheraj, Ilir; Gomceli, Ismail; Turhan, Nesrin; Carberry, Steven; Prehn, Jochen H. M.; GÜRE, ALİ OSMAY; Banerjee, Sreeparna (Oxford University Press (OUP), 2020-09-01)
AKR1B1 and AKR1B10, members of the aldo-keto reductase family of enzymes that participate in the polyol pathway of aldehyde metabolism, are aberrantly expressed in colon cancer. We previously showed that high expression of AKR1B1 (AKR1B1(HIGH)) was associated with enhanced motility, inflammation and poor clinical outcome in colon cancer patients. Using publicly available datasets and ex vivo gene expression analysis (n = 51, Ankara cohort), we have validated our previous in silico finding that AKR1B1(HIGH) ...
Examination of the coping processes of caregivers of children with cancer
Demirtepe Saygılı, Dilek; Bozo Özen, Özlem; Department of Psychology (2013)
The general aim of the present dissertation was to examine the coping processes of the caregivers of children with cancer. It was composed of three studies, whose aims were (1) to reveal the predictors of caregiver distress by using the Transactional Theory of Coping among the caregivers of children with cancer; (2) to identify the factors associated with caregiving process from the caregiver’s perspective qualitatively; (3) to develop and implement an intervention program. Study 1 was conducted with 105 pa...
Characterization and promoter identification of metastasis associated protein 1 in human colorectal carcinoma cell lines
Tunçay Çağatay, Seda; Erson Bensan, Ayşe Elif; Department of Biology (2014)
Metastasis associated protein 1 (MTA1) is a member of the nuclear remodeling and histone deacetylase (NuRD) complex, which is known to repress the expression of several tumor suppressor genes and has been widely linked to tumor metastasis. 15-lipoxygenase-1 (15-LOX-1) is a lipid metabolizing enzyme that has tumor suppressive properties and is silenced by the NuRD complex in colorectal cancer (CRC). We have previously shown that reexpression of 15-LOX-1 inhibited metastasis in CRC, inhibited the inflammatory...
The determinants of life satisfaction in Post-Soviet Azerbaijan
Galip, Hilal; Akçay, Ali Adnan; Department of Sociology (2008)
The study aims to investigate main determinants of life satisfaction in newly independent country, Azerbaijan. Taking into consideration of local and cultural characteristics of the region, this research will give the opportunity for making cross-cultural analysis to understand subjective well-being of people living in the country in transition. Moreover, it provides deeper interpretation of daily experiences of people in different fields of life compared to Soviet period. In the survey, 1030 households wer...
Citation Formats
Y. Micoogullari et al., “Analysis of microsomal epoxide hydrolase tyr113his and his139ARG genotypes with ischemic stroke risk in Turkish population,” 2011, vol. 278, Accessed: 00, 2020. [Online]. Available: