Show/Hide Menu
Hide/Show Apps
anonymousUser
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Açık Bilim Politikası
Açık Bilim Politikası
Frequently Asked Questions
Frequently Asked Questions
Browse
Browse
By Issue Date
By Issue Date
Authors
Authors
Titles
Titles
Subjects
Subjects
Communities & Collections
Communities & Collections
Synthesis and phosphodiester transesterification activity of the La3+-complex of a novel functionalized octadentate ligand
Date
1998-08-06
Author
Baykal, U
Akkaya, EU
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
0
views
0
downloads
Various lanthanide complexes have been shown to promote phosphodiester hydrolysis. Distribution of the available coordination sites of the lanthanides between the ligand and the labile water molecules has proved to be critical in determining the activity and stability of the complex in water at neutral pH. Since the final goal is to conjugate such hydrolytically active molecules to DNA oligomers, the design must include a functionality that can be made reactive in standard conjugation protocols. To that end, we have synthesized a nitrophenyl-derivatized TCMC-La3+ complex, and it is as active as the unmodified TCMC-La3+ in the transesterification of an RNA model substrate.
Subject Keywords
Complex Promoted Hydrolysis
,
Ribozymes
,
Reactivity
,
Europium(İii)
,
Site
,
Rna Cleavage
,
Co(İii) Complex
,
Phosphate Diesters
,
Macrocyclic Complexes;
URI
https://hdl.handle.net/11511/64375
Journal
TETRAHEDRON LETTERS
DOI
https://doi.org/10.1016/s0040-4039(98)01166-6
Collections
Department of Chemistry, Article