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Assessment of immune protective capacity of the recombinant Iron Superoxide Dismutase (FeSOD) from Bordetella pertussis
Date
2017-06-07
Author
Özcengiz, Gülay
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https://hdl.handle.net/11511/74317
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Assessment of immune protective capacities of the recombinant fimbrial protein X (FimX), glutamine binding periplasmic protein (GlnBP) and iron superoxide dismutase (FeSOD) from Bordetella pertussis
Özcengiz, Gülay (null; 2013-07-21)
Assessment of immune protective capacity of the recombinant iron-superoxide dismutase (fesod) from bordetella pertussis
Apak, Aycan; Özcengiz, Gülay; Department of Biology (2011)
Whooping cough (pertussis) is a highly contagious acute respiratory disease caused by the strict human pathogen Bordetella pertussis, a gram-negative coccobacillus. The worldwide mass-vaccination was started in 1940s and to date, a number of whole-cell (Pw) and acellular pertussis vaccine (Pa) formulations were developed. Yet the current vaccines are incapable of providing sustained, lifelong immunity and eliminating subclinical infections, which pose a threat especially for unimmunized infants as well as a...
Assessment of immune protective capacities of the recombinant outer membrane protein q, iron superoxide dismutase and putative lipoprotein from bordetella pertussis
Yılmaz, Çiğdem; Özcengiz, Gülay; Department of Biology (2017)
Pertussis is a contagious disease which is commonly seen among infants and children and caused by a human pathogen known as Bordetella pertussis. There are currently two vaccine types available against the disease; whole-cell (wP) and acellular pertussis (aP) vaccines. Due to the side effects of wP vaccine, aP vaccines are commonly preferred for vaccination. Despite high vaccination coverage, high incidence rates among adolescents and adults have been reported causing the resurgence of pertussis to be the f...
Evaluation of functional changes in akr1b1 and akr1b10 overexpressing colorectal cancer cell lines
Güderer, İsmail; Banerjee, Sreeparna; Department of Biology (2021-2-15)
Aldo-keto reductases (AKRs) are nicotinamide adenine dinucleotide phosphate (NADPH)-dependent enzymes with diverse cellular metabolism functions. AKR1B1 and AKR1B10 are two of the most studied enzymes in the AKR family. AKR1B1 reduces excess glucose into sorbitol using reducing electrons from NADPH, and the hyperactivation of the AKR1B1 pathways is associated with oxidative stress and cell death. AKR1B10 is a poor reductant of glucose but is a vital enzyme that can metabolize retinol and many other drugs an...
Assessment of the role of Neuropeptide Y in the regulation of hematopoietic stem cells
Ulum, Barı; Yanık, Tülin; Department of Biology (2019)
Differentiation, self-renewal and quiescence of Hematopoietic stem cells (HSCs) is tightly regulated and the majority of the immature adult stem cells is quiescent. This protects the HSCs from the strain of constant cell division and depletion of the stem cell pool. The neurotransmitter Neuropeptide Y (NPY) is released from sympathetic nerves in the central or peripheral nervous system. Neuropeptide Y (NPY) is secreted in the bone marrow niche by MSCs and has been shown to indirectly affect HSC function. Ho...
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G. Özcengiz, “Assessment of immune protective capacity of the recombinant Iron Superoxide Dismutase (FeSOD) from Bordetella pertussis,” 2017, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/74317.