Assessment of immune protective capacities of the recombinant fimbrial protein X (FimX), glutamine binding periplasmic protein (GlnBP) and iron superoxide dismutase (FeSOD) from Bordetella pertussis

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2013-07-21

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Özcengiz, Gülay

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https://hdl.handle.net/11511/84515

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Assessment of immune protective capacities of the recombinant outer membrane protein q, iron superoxide dismutase and putative lipoprotein from bordetella pertussis Yılmaz, Çiğdem; Özcengiz, Gülay; Department of Biology (2017) Pertussis is a contagious disease which is commonly seen among infants and children and caused by a human pathogen known as Bordetella pertussis. There are currently two vaccine types available against the disease; whole-cell (wP) and acellular pertussis (aP) vaccines. Due to the side effects of wP vaccine, aP vaccines are commonly preferred for vaccination. Despite high vaccination coverage, high incidence rates among adolescents and adults have been reported causing the resurgence of pertussis to be the f...
Assessment of immune protective capacity of the recombinant Iron Superoxide Dismutase (FeSOD) from Bordetella pertussis Özcengiz, Gülay (2017-06-07)
Assessment of immune protective capacity of the recombinant iron-superoxide dismutase (fesod) from bordetella pertussis Apak, Aycan; Özcengiz, Gülay; Department of Biology (2011) Whooping cough (pertussis) is a highly contagious acute respiratory disease caused by the strict human pathogen Bordetella pertussis, a gram-negative coccobacillus. The worldwide mass-vaccination was started in 1940s and to date, a number of whole-cell (Pw) and acellular pertussis vaccine (Pa) formulations were developed. Yet the current vaccines are incapable of providing sustained, lifelong immunity and eliminating subclinical infections, which pose a threat especially for unimmunized infants as well as a...
Assessment of the immunogenicity and formulation of recombinant proteins from SARS-CoV-2 as vaccine antigens Keser, Duygu; Özcengiz, Gülay; Department of Biology (2022-9-15) COVID-19 is an infectious disease caused by SARS-CoV-2. The virus was first detected in Wuhan, China in late 2019, and the outbreak was declared a pandemic in January 2020 by WHO, and continues to spread worldwide. As of July 2022, more than 575 million confirmed cases have been detected all over the world, and more than 6 million people died from the disease. One of the most important public health measures in combating the spread of infectious diseases is vaccination. Despite the existence of rapidly deve...
Assessment of 17beta-estradiol-estrogen receptor alpha complex-mediated changes in genome-wide methylation and gene expression profiles User, Sırma Damla; Muyan, Mesut; Department of Biology (2016) 17β-estradiol (E2), the most potent estrogen hormone, induces cellular responses primarily through Estrogen Receptor-alpha (ERα), which is a transcription factor. Interfering E2 signaling indicates that E2 is mitogenic for cells, exemplified by MCF7 cells derived from breast adenocarcinoma, synthesizing ERα endogenously. Studies used exogenous expression of ERα in ERα-negative cell lines to examine structural/functional properties of the receptor. What was unexpected from these studies is the observation th...

Citation Formats

G. Özcengiz, “Assessment of immune protective capacities of the recombinant fimbrial protein X (FimX), glutamine binding periplasmic protein (GlnBP) and iron superoxide dismutase (FeSOD) from Bordetella pertussis,” 2013, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/84515.