Development of new methodologies for the synthesis of pyridine derivatives

2016-03-21
Zora, Metin
Kelgökmen, Yılmaz
İbiş, Özge

Suggestions

Development of new synthetic methodologies for indole derivatives
Kılıklı, Ahmet Alper; Balcı, Metin; Department of Chemistry (2010)
Synthesizing nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities on biological systems. Among the various biologically active molecules, indole derivatives are of prime importance on the grounds of their proven clinical roles. Objective of this study is to synthesize new indole derivatives those may contribute treatment of several diseases like their analogues via a recently developed synthetic methodology. Besi...
Development of new synthetic methodologies for isoquinolone and isoindolinone derivatives
Müjde, Berk; Balcı, Metin; Department of Chemistry (2010)
Due to the wide range of physiological activities, heterocycles containing nitrogen and oxygen have always attracted the interest of chemists. The objective of this research is to develop new synthetic routes to the synthesis of isoquinolone and isoindolinone derivatives starting from 2-(2-carboxyethyl)benzoic acid and homophthalic acid, respectively. The half ester produced from 2-(2-carboxyethyl)benzoic acid was an important key compound for the synthesis of new isoquinolone derivatives which are expected...
Development of new synthetic methodologies for the synthesis of unusual isocoumarin and indole derivatives:The chemistry of homophthalic acid
Özcan, Sevil; Balcı, Metin; Department of Chemistry (2007)
Many heterocyclic compounds containing nitrogen, oxygen and sulfur show wide range of physiological activities and their synthesis has always been attracted the interest of chemists. The aim of this research is to develop new synthetic methodologies leading to the synthesis of new derivatives of isocoumarines, indoles, isoquinolines, benzodiazepinones and quinazolines, which have been found to show important biological activities. Starting from homophthalic acid and bishomophthalic acid the corresponding ac...
Development of new synthetic methodologies for aminocyclitols
Ekmekçi, Zeynep; Balcı, Metin; Department of Chemistry (2011)
Aminocyclitols are cyclitols in which at least one of the hydroxyl groups is exchanged with an amino functional group. In turn, they constitute a wide group of natural products with interesting biological properties and are widely distributed throughout. In particular, antibiotics containing an aminocyclitol unit have stimulated the development of synthetic methodologies in the search for analogues with enhanced pharmacological profiles. In this study, three different methods were applied to synthesize diam...
Development of new methodologies for the synthesis of thienopyridazinone and furo- and thienodiazepinedione derivatives
Özer, Merve Sinem; Balcı, Metin; Department of Chemistry (2013)
Some heterocycles are natural compounds and play a major part in biochemical processes. They also have interesting biological activities and pharmacological properties. In this study, new methodologies were developed to synthesize bicyclic heterocyclic compounds consisting of thiophene and furan fused to six- and seven-membered rings, respectively. In the first part, thienopyridazinone derivatives were synthesized. For this purpose, the starting compound was chosen as methyl 2-(2-methoxy-2-oxoethyl)-3-thien...
Citation Formats
M. Zora, Y. Kelgökmen, and Ö. İbiş, “Development of new methodologies for the synthesis of pyridine derivatives,” 2016, vol. 2, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/82193.